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Tead1 TEA domain transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361630, updated on 2-Nov-2024

Summary

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Official Symbol
Tead1provided by RGD
Official Full Name
TEA domain transcription factor 1provided by RGD
Primary source
RGD:1549742
See related
EnsemblRapid:ENSRNOG00000015488 AllianceGenome:RGD:1549742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TEF-1
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including hippo signaling; positive regulation of cell growth; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including embryonic organ development; positive regulation of macromolecule metabolic process; and transition between fast and slow fiber. Predicted to be located in nucleoplasm. Predicted to be part of TEAD-YAP complex. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to human TEAD1 (TEA domain transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 148.6), Muscle (RPKM 145.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tead1 in Genome Data Viewer
Location:
1q33
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (176227175..176445122)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (166791900..167010591)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (177495500..177714795)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene parvin, alpha Neighboring gene small nucleolar RNA SNORA17 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like Neighboring gene uncharacterized LOC120099908 Neighboring gene Ras association domain family member 10 Neighboring gene uncharacterized LOC102547978

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. [CRISPR/Cas9-mediated TEAD1 knockout induces phenotypic modulation of corpus cavernosum smooth muscle cells in diabetic rats with erectile dysfunction]. Zhang T, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2021 Apr 20. PMID 33963717, Free PMC Article
  2. Tumor cell splice variants of the transcription factor TEF-1 induced by SV40 T-antigen transformation. Zuzarte PC, et al. Biochim Biophys Acta, 2000 Dec 15. PMID 11118619
  3. miR-222/VGLL4/YAP-TEAD1 regulatory loop promotes proliferation and invasion of gastric cancer cells. Li N, et al. Am J Cancer Res, 2015. PMID 26045994, Free PMC Article
  4. Cloning and characterization of the mouse alpha1C/A-adrenergic receptor gene and analysis of an alpha1C promoter in cardiac myocytes: role of an MCAT element that binds transcriptional enhancer factor-1 (TEF-1). O'Connell TD, et al. Mol Pharmacol, 2001 May. PMID 11306707
  5. The transcription factor TEAD1 represses smooth muscle-specific gene expression by abolishing myocardin function. Liu F, et al. J Biol Chem, 2014 Feb 7. PMID 24344135, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [CRISPR/Cas9-mediated TEAD1 knockout induces phenotypic modulation of corpus cavernosum smooth muscle cells in diabetic rats with erectile dysfunction].
    Title: [CRISPR/Cas9-mediated TEAD1 knockout induces phenotypic modulation of corpus cavernosum smooth muscle cells in diabetic rats with erectile dysfunction].
  2. Yap1 post-translational modifications favoring its ubiquitination and apoptosis characterize hepatocellular carcinoma (HCC) with better prognosis, whereas conditions favoring the formation of YAP1-TEAD complexes are associated with aggressiveness and acquisition of stemness features by HCC cells
    Title: Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease.
  3. the first evidence demonstrating that TEAD1 is a novel general repressor of smooth muscle-specific gene expression through interfering with myocardin binding to SRF.
    Title: The transcription factor TEAD1 represses smooth muscle-specific gene expression by abolishing myocardin function.
  4. Transcription enhancer factor 1 (Tef-1)binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.
    Title: Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic heart tube morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lateral mesoderm development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within notochord development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within paraxial mesoderm development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transition between fast and slow fiber ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TEAD-YAP complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcriptional enhancer factor TEF-1
Names
TEA domain family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198589.2 → NP_001185518.1  transcriptional enhancer factor TEF-1

    See identical proteins and their annotated locations for NP_001185518.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZKU4, A6I870
    Related
    ENSRNOP00000021020.4, ENSRNOT00000021020.6
    Conserved Domains (2) summary
    smart00426
    Location:15 → 82
    TEA; TEA domain
    pfam17725
    Location:204 → 412
    YBD; YAP binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    176227175..176445122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267472.1 → XP_063123542.1  transcriptional enhancer factor TEF-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2N3

  2. XM_063267482.1 → XP_063123552.1  transcriptional enhancer factor TEF-1 isoform X6

  3. XM_063267476.1 → XP_063123546.1  transcriptional enhancer factor TEF-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2N3

  4. XM_063267458.1 → XP_063123528.1  transcriptional enhancer factor TEF-1 isoform X2

  5. XM_063267471.1 → XP_063123541.1  transcriptional enhancer factor TEF-1 isoform X4

  6. XM_063267456.1 → XP_063123526.1  transcriptional enhancer factor TEF-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2N3

  7. XM_063267467.1 → XP_063123537.1  transcriptional enhancer factor TEF-1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y8C5
    Related
    ENSRNOP00000077946.1, ENSRNOT00000104208.2

  8. XM_039082788.2 → XP_038938716.1  transcriptional enhancer factor TEF-1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZM31
    Related
    ENSRNOP00000092848.1, ENSRNOT00000105758.2
    Conserved Domains (2) summary
    smart00426
    Location:15 → 74
    TEA; TEA domain
    pfam17725
    Location:179 → 387
    YBD; YAP binding domain

  9. XM_039082763.2 → XP_038938691.2  transcriptional enhancer factor TEF-1 isoform X7

Nucleotide Protein Strain
Heading Accession and Version

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