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Ccp110 centriolar coiled-coil protein 110 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361634, updated on 2-Nov-2024

Summary

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Official Symbol
Ccp110provided by RGD
Official Full Name
centriolar coiled-coil protein 110provided by RGD
Primary source
RGD:1310509
See related
EnsemblRapid:ENSRNOG00000027405 AllianceGenome:RGD:1310509
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cp110; RGD1310509
Summary
Predicted to be involved in microtubule organizing center organization; regulation of cilium assembly; and regulation of cytokinesis. Predicted to be located in centrosome. Predicted to be part of protein-containing complex. Predicted to be active in centriole. Orthologous to human CCP110 (centriolar coiled-coil protein 110). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 175.1), Testes (RPKM 131.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccp110 in Genome Data Viewer
Location:
1q35
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (182475571..182504235)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (173042238..173072873)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (188417012..188444991)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099917 Neighboring gene transmembrane channel-like 5 Neighboring gene glycerophosphodiester phosphodiesterase 1 Neighboring gene VPS35 endosomal protein sorting factor like Neighboring gene small nucleolar RNA SNORA24 Neighboring gene lysine-rich nucleolar protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Polo kinase Plk4 functions in centriole duplication. Habedanck R, et al. Nat Cell Biol, 2005 Nov. PMID 16244668
  2. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Chen Z, et al. Dev Cell, 2002 Sep. PMID 12361598
  3. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. Li J, et al. Nature, 2013 Mar 14. PMID 23486064, Free PMC Article
  4. Cep97 and CP110 suppress a cilia assembly program. Spektor A, et al. Cell, 2007 Aug 24. PMID 17719545
  5. Plk4-induced centriole biogenesis in human cells. Kleylein-Sohn J, et al. Dev Cell, 2007 Aug. PMID 17681131

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome duplication ISO
Inferred from Sequence Orthology
more info
  
involved_in ciliary basal body organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ciliary basal body organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centriolar coiled-coil protein of 110 kDa
Names
centriolar coiled coil protein 110kDa
centrosomal protein of 110 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108501.1 → NP_001101971.1  centriolar coiled-coil protein of 110 kDa

    See identical proteins and their annotated locations for NP_001101971.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473956
    UniProtKB/TrEMBL
    A0A8I5ZNZ6, A6I8I5, D4A3J9
    Related
    ENSRNOP00000082093.2, ENSRNOT00000114744.2
    Conserved Domains (1) summary
    pfam16025
    Location:31 → 106
    CALM_bind; Calcium-dependent calmodulin binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    182475571..182504235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082809.2 → XP_038938737.1  centriolar coiled-coil protein of 110 kDa isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNZ6, A6I8I5, D4A3J9
    Conserved Domains (1) summary
    pfam16025
    Location:31 → 106
    CALM_bind; Calcium-dependent calmodulin binding

  2. XM_063267558.1 → XP_063123628.1  centriolar coiled-coil protein of 110 kDa isoform X3

    UniProtKB/TrEMBL
    A0A8I6GDT4, A6I8I4

  3. XM_063267560.1 → XP_063123630.1  centriolar coiled-coil protein of 110 kDa isoform X4

  4. XM_039082822.2 → XP_038938750.1  centriolar coiled-coil protein of 110 kDa isoform X3

    UniProtKB/TrEMBL
    A0A8I6GDT4, A6I8I4, A6I8I6
    Related
    ENSRNOP00000035030.7, ENSRNOT00000037870.8
    Conserved Domains (1) summary
    pfam16025
    Location:31 → 106
    CALM_bind; Calcium-dependent calmodulin binding

  5. XM_039082825.2 → XP_038938753.1  centriolar coiled-coil protein of 110 kDa isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZJN5, A6I8I6
    Related
    ENSRNOP00000078065.1, ENSRNOT00000111681.2
    Conserved Domains (1) summary
    pfam16025
    Location:31 → 106
    CALM_bind; Calcium-dependent calmodulin binding

  6. XM_039082821.2 → XP_038938749.1  centriolar coiled-coil protein of 110 kDa isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNZ6
    Conserved Domains (1) summary
    pfam16025
    Location:31 → 106
    CALM_bind; Calcium-dependent calmodulin binding

  7. XM_063267559.1 → XP_063123629.1  centriolar coiled-coil protein of 110 kDa isoform X4

  8. XM_063267568.1 → XP_063123638.1  centriolar coiled-coil protein of 110 kDa isoform X6

  9. XM_039082813.2 → XP_038938741.1  centriolar coiled-coil protein of 110 kDa isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNZ6, A6I8I5, D4A3J9
    Conserved Domains (1) summary
    pfam16025
    Location:31 → 106
    CALM_bind; Calcium-dependent calmodulin binding

  10. XM_039082811.2 → XP_038938739.1  centriolar coiled-coil protein of 110 kDa isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNZ6, A6I8I5, D4A3J9
    Conserved Domains (1) summary
    pfam16025
    Location:31 → 106
    CALM_bind; Calcium-dependent calmodulin binding

  11. XM_063267557.1 → XP_063123627.1  centriolar coiled-coil protein of 110 kDa isoform X3

    UniProtKB/TrEMBL
    A0A8I6GDT4, A6I8I4

  12. XM_063267544.1 → XP_063123614.1  centriolar coiled-coil protein of 110 kDa isoform X2

  13. XM_039082816.2 → XP_038938744.1  centriolar coiled-coil protein of 110 kDa isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNZ6, A6I8I5, D4A3J9
    Conserved Domains (1) summary
    pfam16025
    Location:31 → 106
    CALM_bind; Calcium-dependent calmodulin binding

  14. XM_039082814.2 → XP_038938742.1  centriolar coiled-coil protein of 110 kDa isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNZ6, A6I8I5, D4A3J9
    Conserved Domains (1) summary
    pfam16025
    Location:31 → 106
    CALM_bind; Calcium-dependent calmodulin binding
Nucleotide Protein Strain
Heading Accession and Version

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