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Vps35l VPS35 endosomal protein sorting factor like [ Rattus norvegicus (Norway rat) ]

Gene ID: 361635, updated on 2-Nov-2024

Summary

Official Symbol
Vps35lprovided by RGD
Official Full Name
VPS35 endosomal protein sorting factor likeprovided by RGD
Primary source
RGD:1564485
See related
EnsemblRapid:ENSRNOG00000016063 AllianceGenome:RGD:1564485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in Golgi to plasma membrane transport and endocytic recycling. Predicted to be located in membrane. Predicted to be active in endosome. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome. Orthologous to human VPS35L (VPS35 endosomal protein sorting factor like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 104.9), Adrenal (RPKM 99.8) and 9 other tissues See more
Orthologs
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Genomic context

See Vps35l in Genome Data Viewer
Location:
1q35
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (182507576..182611021)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (173076219..173179663)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (188448517..188552268)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase 1 Neighboring gene centriolar coiled-coil protein 110 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene lysine-rich nucleolar protein 1 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene IQ motif containing K

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in Golgi to plasma membrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endocytic recycling IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytic recycling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
VPS35 endosomal protein-sorting factor-like
Names
UPF0505 protein C16orf62 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017463.2NP_001017463.1  VPS35 endosomal protein-sorting factor-like isoform 2

    See identical proteins and their annotated locations for NP_001017463.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q5XI83
    UniProtKB/TrEMBL
    A0A8I6AHK5
    Related
    ENSRNOP00000043528.3, ENSRNOT00000050393.4
  2. NM_001399656.1NP_001386585.1  VPS35 endosomal protein-sorting factor-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000093416.1, ENSRNOT00000105295.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    182507576..182611021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589391.3XP_017444880.1  VPS35 endosomal protein-sorting factor-like isoform X1

    UniProtKB/TrEMBL
    A0A8I6AHK5
    Related
    ENSRNOP00000102852.1, ENSRNOT00000160566.1