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Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361655, updated on 2-Nov-2024

Summary

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Official Symbol
Tial1provided by RGD
Official Full Name
Tia1 cytotoxic granule-associated RNA binding protein-like 1provided by RGD
Primary source
RGD:1595845
See related
EnsemblRapid:ENSRNOG00000020271 AllianceGenome:RGD:1595845
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA 3'-UTR AU-rich region binding activity and protein-RNA adaptor activity. Predicted to be involved in negative regulation of cell population proliferation; positive regulation of hippo signaling; and positive regulation of miRNA-mediated gene silencing. Predicted to act upstream of or within germ cell development; positive regulation of stem cell proliferation; and stem cell division. Located in cytoplasmic stress granule. Part of ribonucleoprotein complex. Biomarker of transient cerebral ischemia. Orthologous to human TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 146.0), Brain (RPKM 139.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tial1 in Genome Data Viewer
Location:
1q37
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (192438794..192475520, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (183008358..183045092, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199844854..199865843, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485178 Neighboring gene uncharacterized LOC103691239 Neighboring gene regulator of G-protein signaling 10 Neighboring gene uncharacterized LOC134485179 Neighboring gene 40S ribosomal protein S19 pseudogene Neighboring gene ribosomal protein S2, pseudogene 13 Neighboring gene uncharacterized LOC134483924

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Immunohistochemical evidence for a crossed cholecystokinin corticostriatal pathway in the rat. Morino P, et al. Neurosci Lett, 1992 Dec 14. PMID 1300485
  2. RNA-binding protein TIAR is essential for primordial germ cell development. Beck AR, et al. Proc Natl Acad Sci U S A, 1998 Mar 3. PMID 9482885, Free PMC Article
  3. Expression of the RNA-binding protein TIAR is increased in neurons after ischemic cerebral injury. Jin K, et al. J Neurosci Res, 2000 Mar 15. PMID 10700014
  4. Alternative splicing: a pivotal step between eukaryotic transcription and translation. Kornblihtt AR, et al. Nat Rev Mol Cell Biol, 2013 Mar. PMID 23385723
  5. U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. Zhu H, et al. Mol Cell Biol, 2003 Sep. PMID 12917321, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TIAR regulates the relative expression of TIA-1 isoforms.
    Title: Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC109552

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-RNA adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within germ cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of miRNA-mediated gene silencing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within stem cell division ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nucleolysin TIAR
Names
RNA binding protein TIAR (TIA-1 related)
Tial 1 cytotoxic granule-associated RNA- binding protein-like 1
Tial1 cytotoxic granule-associated RNA binding protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013193.1 → NP_001013211.1  nucleolysin TIAR

    See identical proteins and their annotated locations for NP_001013211.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091409
    UniProtKB/TrEMBL
    A0A9K3Y710, F1LQ36, Q5BJN3
    Related
    ENSRNOP00000027463.5, ENSRNOT00000027463.7
    Conserved Domains (3) summary
    cd12620
    Location:222 → 294
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12616
    Location:10 → 107
    RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:113 → 192
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    192438794..192475520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083035.2 → XP_038938963.1  nucleolysin TIAR isoform X2

    Related
    ENSRNOP00000091228.2, ENSRNOT00000102400.2
    Conserved Domains (3) summary
    cd12620
    Location:166 → 238
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:57 → 136
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:1 → 51
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_006230310.5 → XP_006230372.1  nucleolysin TIAR isoform X1

    See identical proteins and their annotated locations for XP_006230372.1

    UniProtKB/TrEMBL
    A0A8I6GIU6, A6IA03
    Conserved Domains (3) summary
    cd12620
    Location:205 → 277
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12616
    Location:10 → 90
    RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:96 → 175
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

  3. XM_063267805.1 → XP_063123875.1  nucleolysin TIAR isoform X2

  4. XM_063267806.1 → XP_063123876.1  nucleolysin TIAR isoform X4

  5. XM_063267807.1 → XP_063123877.1  nucleolysin TIAR isoform X5

    UniProtKB/TrEMBL
    A6IA05

  6. XM_063267812.1 → XP_063123882.1  nucleolysin TIAR isoform X5

    UniProtKB/TrEMBL
    A6IA05

  7. XM_006230312.5 → XP_006230374.1  nucleolysin TIAR isoform X3

    See identical proteins and their annotated locations for XP_006230374.1

    Conserved Domains (3) summary
    cd12620
    Location:222 → 294
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12616
    Location:10 → 107
    RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:113 → 192
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

  8. XM_006230313.5 → XP_006230375.1  nucleolysin TIAR isoform X3

    See identical proteins and their annotated locations for XP_006230375.1

    Conserved Domains (3) summary
    cd12620
    Location:222 → 294
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12616
    Location:10 → 107
    RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:113 → 192
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

RNA

  1. XR_010054659.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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