Bub3 BUB3 mitotic checkpoint protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bub3provided by RGD
Official Full Name: BUB3 mitotic checkpoint proteinprovided by RGD
Primary source: RGD:1306654
See related: EnsemblRapid:ENSRNOG00000020643 AllianceGenome:RGD:1306654
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aa2-050
Summary: Predicted to enable ubiquitin binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore. Predicted to act upstream of or within mitotic sister chromatid segregation. Predicted to be located in nucleoplasm. Predicted to be part of bub1-bub3 complex and mitotic checkpoint complex. Predicted to be active in kinetochore. Orthologous to human BUB3 (BUB3 mitotic checkpoint protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 389.1), Spleen (RPKM 268.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (195760532..195771140)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (186330358..186340969)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (203526853..203537459)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in protein localization to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in kinetochore	ISO Inferred from Sequence Orthology more info
part_of mitotic checkpoint complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitotic checkpoint protein BUB3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047906.2 → NP_001041371.2 mitotic checkpoint protein BUB3

See identical proteins and their annotated locations for NP_001041371.2

Status: VALIDATED

Source sequence(s)

BC099199, DY575212

UniProtKB/TrEMBL

A0A0G2JU63, Q4FZS2

Related

ENSRNOP00000101461.1, ENSRNOT00000158776.1

Conserved Domains (2) summary

sd00039
Location:17 → 54

7WD40; WD40 repeat [structural motif]

cl29593
Location:14 → 296

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

195760532..195771140

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083223.2 → XP_038939151.1 mitotic checkpoint protein BUB3 isoform X1

Conserved Domains (2) summary

sd00039
Location:19 → 54

7WD40; WD40 repeat [structural motif]

cl29593
Location:3 → 216

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...