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Unc93b1 unc-93 homolog B1, TLR signaling regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 361689, updated on 2-Nov-2024

Summary

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Official Symbol
Unc93b1provided by RGD
Official Full Name
unc-93 homolog B1, TLR signaling regulatorprovided by RGD
Primary source
RGD:1311984
See related
EnsemblRapid:ENSRNOG00000017703 AllianceGenome:RGD:1311984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Unc93b
Summary
Predicted to enable Toll-like receptor binding activity. Predicted to be involved in endolysosomal toll-like receptor signaling pathway and intracellular protein transport. Predicted to act upstream of or within several processes, including T cell antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; and positive regulation of cytokine production. Predicted to be located in early phagosome and endoplasmic reticulum. Predicted to be active in endosome and lysosome. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human UNC93B1 (unc-93 homolog B1, TLR signaling regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 497.9), Lung (RPKM 149.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Unc93b1 in Genome Data Viewer
Location:
1q43
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210596639..210607579)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201167388..201178343)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219172987..219183941)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S8 Neighboring gene aldehyde dehydrogenase 3 family, member B1 Neighboring gene aldehyde dehydrogenase 3 family, member B3 Neighboring gene aldehyde dehydrogenase 3 family, member B3-like, pseudogene 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2, pseudogene 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response. Koehn J, et al. Hum Immunol, 2007 Nov. PMID 18082565
  2. Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi. Caetano BC, et al. J Immunol, 2011 Aug 15. PMID 21753151, Free PMC Article
  3. BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid dendritic cells. Defays A, et al. Blood, 2011 Jul 21. PMID 21642595
  4. IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Isnardi I, et al. Immunity, 2008 Nov 14. PMID 19006693, Free PMC Article
  5. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Eidenschenk C, et al. Proc Natl Acad Sci U S A, 2010 May 25. PMID 20457904, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi.
    Title: Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Toll-like receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Toll-like receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 3 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 7 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in toll-like receptor 7 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 9 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in toll-like receptor 9 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in early phagosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein unc-93 homolog B1
Names
unc-93 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403514.1 → NP_001390443.1  protein unc-93 homolog B1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    210596639..210607579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589435.2 → XP_017444924.1  protein unc-93 homolog B1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZSD6
    Related
    ENSRNOP00000081147.2, ENSRNOT00000110255.2

  2. XM_039083685.1 → XP_038939613.1  protein unc-93 homolog B1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW71, D3ZDJ4
    Related
    ENSRNOP00000024018.5, ENSRNOT00000024018.8
    Conserved Domains (1) summary
    cd17408
    Location:54 → 510
    MFS_unc93B1; Protein unc-93 homolog B1 of the Major Facilitator Superfamily of transporters

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108513.1: Suppressed sequence

    Description
    NM_001108513.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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