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Rps6ka4 ribosomal protein S6 kinase A4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361715, updated on 18-Sep-2024

Summary

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Official Symbol
Rps6ka4provided by RGD
Official Full Name
ribosomal protein S6 kinase A4provided by RGD
Primary source
RGD:1307277
See related
EnsemblRapid:ENSRNOG00000021117 AllianceGenome:RGD:1307277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc88b
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including histone-serine phosphorylation; interleukin-1-mediated signaling pathway; and positive regulation of histone modification. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human RPS6KA4 (ribosomal protein S6 kinase A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 65.9), Lung (RPKM 62.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rps6ka4 in Genome Data Viewer
Location:
1q43
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213451026..213461982, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204021805..204032781, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222087328..222098284, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 12 Neighboring gene PRELI domain containing 1, pseudogene 5 Neighboring gene coiled-coil domain containing 88B Neighboring gene uncharacterized LOC134483961

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB). Tomás-Zuber M, et al. J Biol Chem, 2001 Feb 23. PMID 11035004
  2. RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). Pierrat B, et al. J Biol Chem, 1998 Nov 6. PMID 9792677
  3. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M. Nat Rev Mol Cell Biol, 2006 Feb. PMID 16421520
  4. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. Soloaga A, et al. EMBO J, 2003 Jun 2. PMID 12773393, Free PMC Article
  5. Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. Wang B, et al. Arterioscler Thromb Vasc Biol, 2010 Mar. PMID 20018936

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3S28 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein modification ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase alpha-4
Names
coiled-coil domain containing 88B
ribosomal protein S6 kinase, polypeptide 4
NP_001101987.2
XP_038939947.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108517.2 → NP_001101987.2  ribosomal protein S6 kinase alpha-4

    Status: VALIDATED

    Source sequence(s)
    AW251264, BF407559, BQ194971, BU671341, CB700259, CB737401, DN932052, FM035808, FM059731
    UniProtKB/TrEMBL
    A6HZI4, D3ZSB7
    Related
    ENSRNOP00000028678.6, ENSRNOT00000028678.9
    Conserved Domains (2) summary
    cd05614
    Location:32 → 364
    STKc_MSK2_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
    cl21453
    Location:404 → 714
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    213451026..213461982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084019.2 → XP_038939947.1  ribosomal protein S6 kinase alpha-4 isoform X1

    UniProtKB/TrEMBL
    A6HZI4
    Conserved Domains (1) summary
    cl21453
    Location:1 → 301
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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