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Naa40 N(alpha)-acetyltransferase 40, NatD catalytic subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 361718, updated on 2-Nov-2024

Summary

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Official Symbol
Naa40provided by RGD
Official Full Name
N(alpha)-acetyltransferase 40, NatD catalytic subunitprovided by RGD
Primary source
RGD:1565838
See related
EnsemblRapid:ENSRNOG00000021179 AllianceGenome:RGD:1565838
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nat11; RGD1565838
Summary
Predicted to enable histone H2A acetyltransferase activity; histone H4 acetyltransferase activity; and peptide-serine-alpha-N-acetyltransferase activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in centriolar satellite; cytosol; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human NAA40 (N-alpha-acetyltransferase 40, NatD catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 70.9), Thymus (RPKM 59.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Naa40 in Genome Data Viewer
Location:
1q43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213842686..213860079, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204410636..204430890, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222478021..222495382, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 1 Neighboring gene heterogeneous nuclear ribonucleoprotein R, pseudogene 2 Neighboring gene cytochrome c oxidase subunit 8A Neighboring gene REST corepressor 2 Neighboring gene microtubule affinity regulating kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Liver Patt1 deficiency protects male mice from age-associated but not high-fat diet-induced hepatic steatosis. Liu Y, et al. J Lipid Res, 2012 Mar. PMID 22231784, Free PMC Article
  2. The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD. Magin RS, et al. Structure, 2015 Feb 3. PMID 25619998, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H2A acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2A acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide-serine-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-serine-alpha-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 40
Names
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog
N-acetyltransferase 11
NP_001101988.1
XP_038940000.1
XP_038940010.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108518.1 → NP_001101988.1  N-alpha-acetyltransferase 40

    See identical proteins and their annotated locations for NP_001101988.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A6HZP0, D3ZZQ5
    Related
    ENSRNOP00000028759.4, ENSRNOT00000028759.7
    Conserved Domains (1) summary
    pfam00583
    Location:80 → 188
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    213842686..213860079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084082.2 → XP_038940010.1  N-alpha-acetyltransferase 40 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A7S4

  2. XM_039084072.2 → XP_038940000.1  N-alpha-acetyltransferase 40 isoform X1

    Conserved Domains (1) summary
    pfam00583
    Location:94 → 135
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein Strain
Heading Accession and Version

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