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Spindoc spindlin interactor and repressor of chromatin binding [ Rattus norvegicus (Norway rat) ]

Gene ID: 361719, updated on 2-Nov-2024

Summary

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Official Symbol
Spindocprovided by RGD
Official Full Name
spindlin interactor and repressor of chromatin bindingprovided by RGD
Primary source
RGD:1308106
See related
EnsemblRapid:ENSRNOG00000025061 AllianceGenome:RGD:1308106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308106
Summary
Predicted to be involved in DNA damage response and negative regulation of DNA-templated transcription. Predicted to be active in nucleus and site of DNA damage. Orthologous to human SPINDOC (spindlin interactor and repressor of chromatin binding). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 64.9), Lung (RPKM 44.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spindoc in Genome Data Viewer
Location:
1q43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213971995..213995162, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204541647..204565109, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222606302..222628839, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene REST corepressor 2 Neighboring gene microtubule affinity regulating kinase 2 Neighboring gene uncharacterized LOC134483963 Neighboring gene zinc finger translocation associated Neighboring gene reticulon 3 Neighboring gene uncharacterized LOC102551693 Neighboring gene atlastin GTPase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. Bae N, et al. J Biol Chem, 2017 Dec 22. PMID 29061846, Free PMC Article
  2. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
spindlin interactor and repressor of chromatin-binding protein
Names
uncharacterized protein C11orf84 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399680.1 → NP_001386609.1  spindlin interactor and repressor of chromatin-binding protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000075651.2, ENSRNOT00000083157.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    213971995..213995162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230864.5 → XP_006230926.1  spindlin interactor and repressor of chromatin-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A0G2KB48

  2. XM_039084096.2 → XP_038940024.1  spindlin interactor and repressor of chromatin-binding protein isoform X1

    UniProtKB/TrEMBL
    A6HZP6, D4AED1
    Related
    ENSRNOP00000029940.6, ENSRNOT00000034477.8
    Conserved Domains (1) summary
    pfam18658
    Location:36 → 100
    zf-C2H2_12; Zinc-finger C2H2-type

RNA

  1. XR_350851.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134575.1: Suppressed sequence

    Description
    NM_001134575.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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