U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Uqcc2 ubiquinol-cytochrome c reductase complex assembly factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361805, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Uqcc2provided by RGD
Official Full Name
ubiquinol-cytochrome c reductase complex assembly factor 2provided by RGD
Primary source
RGD:1306917
See related
EnsemblRapid:ENSRNOG00000025909 AllianceGenome:RGD:1306917
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
M19; Mnf1; RGD1306917
Summary
Predicted to be involved in several processes, including mitochondrial respiratory chain complex III assembly; positive regulation of mitochondrial translation; and regulation of insulin secretion. Predicted to be located in mitochondrion and nuclear body. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 7. Orthologous to human UQCC2 (ubiquinol-cytochrome c reductase complex assembly factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 325.3), Heart (RPKM 258.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Uqcc2 in Genome Data Viewer
Location:
20p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5204682..5217080, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5202837..5214541, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5712200..5723902, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-trisphosphate receptor, type 3 Neighboring gene uncharacterized LOC134483859 Neighboring gene uncharacterized LOC120098963 Neighboring gene inositol hexakisphosphate kinase 3 Neighboring gene uncharacterized LOC108353257

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. M19 modulates skeletal muscle differentiation and insulin secretion in pancreatic β-cells through modulation of respiratory chain activity. Cambier L, et al. PLoS One, 2012. PMID 22363741, Free PMC Article
  2. Association of a novel mitochondrial protein M19 with mitochondrial nucleoids. Sumitani M, et al. J Biochem, 2009 Nov. PMID 19643811
  3. Mutations in the UQCC1-interacting protein, UQCC2, cause human complex III deficiency associated with perturbed cytochrome b protein expression. Tucker EJ, et al. PLoS Genet, 2013. PMID 24385928, Free PMC Article
  4. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex III assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex III assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex III assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of oxidative phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of skeletal muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial nucleoid ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquinol-cytochrome-c reductase complex assembly factor 2
Names
mitochondrial nucleoid factor 1
mitochondrial protein M19
NP_001101998.1
XP_038954739.1
XP_038954740.1
XP_038954741.1
XP_063135283.1
XP_063135284.1
XP_063135285.1
XP_063135286.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108528.1 → NP_001101998.1  ubiquinol-cytochrome-c reductase complex assembly factor 2

    See identical proteins and their annotated locations for NP_001101998.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473988
    UniProtKB/Swiss-Prot
    B5DFN3
    UniProtKB/TrEMBL
    D3Z949

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    5204682..5217080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279213.1 → XP_063135283.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X1

  2. XM_039098811.2 → XP_038954739.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QIN0

  3. XM_063279214.1 → XP_063135284.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X2

  4. XM_063279216.1 → XP_063135286.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X3

    Related
    ENSRNOP00000036200.5, ENSRNOT00000036871.7

  5. XM_063279215.1 → XP_063135285.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X3

  6. XM_039098812.2 → XP_038954740.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8L2QIN0

  7. XM_039098813.2 → XP_038954741.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8L2QIN0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5DFN3.1 GenPept UniProtKB/Swiss-Prot:B5DFN3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools