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Hnrnph3 heterogeneous nuclear ribonucleoprotein H3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361838, updated on 17-Aug-2024

Summary

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Symbol
Hnrnph3provided by RGD
Full Name
heterogeneous nuclear ribonucleoprotein H3provided by RGD
Primary source
RGD:1310019
See related
EnsemblRapid:ENSRNOG00000048193 AllianceGenome:RGD:1310019
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hnrph3
Summary
Predicted to enable RNA binding activity. Predicted to be involved in epithelial cell differentiation and regulation of RNA splicing. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Orthologous to human HNRNPH3 (heterogeneous nuclear ribonucleoprotein H3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 149.3), Spleen (RPKM 133.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hnrnph3 in Genome Data Viewer
Location:
20q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (25619540..25624397)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (25616400..25625814)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (27167926..27178172)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene phenazine biosynthesis-like protein domain containing 1 Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene RUN and FYVE domain containing 2 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene solute carrier family 25 member 16 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene small nucleolar RNA SNORA70

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc. Mauger DM, et al. Mol Cell Biol, 2008 Sep. PMID 18573884, Free PMC Article
  2. Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Buhrke T, et al. Dev Growth Differ, 2011 Apr. PMID 21492153
  3. PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex. Todd MA, et al. J Proteome Res, 2012 Aug 3. PMID 22720776
  4. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
  5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein H3
Names
heterogeneous nuclear ribonucleoprotein H3 (2H9)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108532.1 → NP_001102002.1  heterogeneous nuclear ribonucleoprotein H3

    See identical proteins and their annotated locations for NP_001102002.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473988
    UniProtKB/TrEMBL
    A6JKZ7, D4ABK7
    Related
    ENSRNOP00000029804.5, ENSRNOT00000032600.7
    Conserved Domains (2) summary
    cd12735
    Location:195 → 269
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    25619540..25624397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256380.5 → XP_006256442.2  heterogeneous nuclear ribonucleoprotein H3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JVA2, A6JKZ9, D4ABK7
    Related
    ENSRNOP00000069405.3, ENSRNOT00000077525.3
    Conserved Domains (2) summary
    cd12735
    Location:180 → 254
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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