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Traf3ip2 Traf3 interacting protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361857, updated on 2-Nov-2024

Summary

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Official Symbol
Traf3ip2provided by RGD
Official Full Name
Traf3 interacting protein 2provided by RGD
Primary source
RGD:1593240
See related
EnsemblRapid:ENSRNOG00000000595 AllianceGenome:RGD:1593240
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304768
Summary
Predicted to enable signaling receptor binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and lymphocyte differentiation. Predicted to act upstream of or within B cell apoptotic process. Predicted to be active in cytoplasmic vesicle and nucleus. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis and psoriasis 13. Orthologous to human TRAF3IP2 (TRAF3 interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 67.2), Uterus (RPKM 57.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Traf3ip2 in Genome Data Viewer
Location:
20q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (44565992..44609240)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (43011405..43054654)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (44679861..44722874)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349081 Neighboring gene claudin-7 pseudogene Neighboring gene FYN proto-oncogene, Src family tyrosine kinase Neighboring gene uncharacterized LOC108349084 Neighboring gene uncharacterized LOC134483822 Neighboring gene uncharacterized LOC120098872 Neighboring gene uncharacterized LOC134483824

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling. Ryzhakov G, et al. J Immunol, 2012 Nov 15. PMID 23066157
  2. Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Qian Y, et al. Immunity, 2004 Oct. PMID 15485634
  3. IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail. Ho AW, et al. J Immunol, 2010 Jul 15. PMID 20554964, Free PMC Article
  4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112844

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell affinity maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell mediated immunity ISO
Inferred from Sequence Orthology
more info
  
involved_in CD40 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in T-helper 17 type immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-17 ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in eosinophil homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in eosinophil mediated immunity ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of T cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within humoral immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-17-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-17A-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte activation involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in lymph node development ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mucus secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to P-body ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in skin development ISO
Inferred from Sequence Orthology
more info
  
involved_in spleen development ISO
Inferred from Sequence Orthology
more info
  
involved_in transitional two stage B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in type 2 immune response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin ligase TRAF3IP2
Names
adapter protein CIKS
NP_001037713.1
XP_006256594.1
XP_038954814.1
XP_038954815.1
XP_063135386.1
XP_063135387.1
XP_063135388.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044248.1 → NP_001037713.1  E3 ubiquitin ligase TRAF3IP2

    See identical proteins and their annotated locations for NP_001037713.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100099
    UniProtKB/TrEMBL
    F7ENK0, Q498R8
    Related
    ENSRNOP00000000728.7, ENSRNOT00000000728.7
    Conserved Domains (1) summary
    pfam08357
    Location:394 → 536
    SEFIR; SEFIR domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    44565992..44609240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279316.1 → XP_063135386.1  E3 ubiquitin ligase TRAF3IP2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLR0
    Related
    ENSRNOP00000095663.1, ENSRNOT00000119731.2

  2. XM_039098886.2 → XP_038954814.1  E3 ubiquitin ligase TRAF3IP2 isoform X3

  3. XM_006256532.5 → XP_006256594.1  E3 ubiquitin ligase TRAF3IP2 isoform X1

    See identical proteins and their annotated locations for XP_006256594.1

    UniProtKB/TrEMBL
    F7ENK0, Q498R8
    Conserved Domains (1) summary
    pfam08357
    Location:394 → 536
    SEFIR; SEFIR domain

  4. XM_063279317.1 → XP_063135387.1  E3 ubiquitin ligase TRAF3IP2 isoform X4

  5. XM_063279318.1 → XP_063135388.1  E3 ubiquitin ligase TRAF3IP2 isoform X5

    UniProtKB/TrEMBL
    A6KIH0

  6. XM_039098887.2 → XP_038954815.1  E3 ubiquitin ligase TRAF3IP2 isoform X6

    Conserved Domains (1) summary
    cl23749
    Location:1 → 87
    TIR_2; TIR domain
Nucleotide Protein Strain
Heading Accession and Version

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