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Arhgef28 Rho guanine nucleotide exchange factor 28 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361882, updated on 17-Aug-2024

Summary

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Official Symbol
Arhgef28provided by RGD
Official Full Name
Rho guanine nucleotide exchange factor 28provided by RGD
Primary source
RGD:1307061
See related
EnsemblRapid:ENSRNOG00000016544 AllianceGenome:RGD:1307061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rgnef
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cell morphogenesis and regulation of Rho protein signal transduction. Predicted to act upstream of or within central nervous system neuron axonogenesis and neurofilament cytoskeleton organization. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human ARHGEF28 (Rho guanine nucleotide exchange factor 28). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 176.9), Lung (RPKM 79.8) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q12
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (30998292..31294757, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (29263888..29560595, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (25738514..26011429, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ATP synthase F1 subunit beta, pseudogene 2 Neighboring gene small ribosomal subunit protein uS15-like Neighboring gene small nucleolar RNA SNORA40 Neighboring gene uncharacterized LOC134485583 Neighboring gene UTP15, small subunit processome component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules. van Horck FP, et al. J Biol Chem, 2001 Feb 16. PMID 11058585
  2. RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration. Lin H, et al. Hum Mol Genet, 2005 Dec 1. PMID 16236762
  3. Control of axonal branching and synapse formation by focal adhesion kinase. Rico B, et al. Nat Neurosci, 2004 Oct. PMID 15378065, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within central nervous system neuron axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in neurofilament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurofilament cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 28
Names
190 kDa guanine nucleotide exchange factor
Rho guanine nucleotide exchange factor (GEF) 28
Rho-guanine nucleotide exchange factor
p190-RhoGEF
p190RhoGEF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415065.1 → NP_001401994.1  rho guanine nucleotide exchange factor 28

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P0C6P5
    UniProtKB/TrEMBL
    A6I534
    Related
    ENSRNOP00000059196.2, ENSRNOT00000065143.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    30998292..31294757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102531.2 → XP_038958459.1  rho guanine nucleotide exchange factor 28 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZW57, A6I534
    Related
    ENSRNOP00000083894.1, ENSRNOT00000115432.2
    Conserved Domains (4) summary
    smart00325
    Location:866 → 1055
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd14680
    Location:1100 → 1200
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    pfam17380
    Location:1368 → 1536
    DUF5401; Family of unknown function (DUF5401)
    cd20876
    Location:659 → 719
    C1_p190RhoGEF; protein kinase C conserved region 1 (C1 domain) found in 190 kDa guanine nucleotide exchange factor (p190RhoGEF) and similar proteins

  2. XM_063282028.1 → XP_063138098.1  rho guanine nucleotide exchange factor 28 isoform X2

    UniProtKB/TrEMBL
    A0A8L2UN35
    Related
    ENSRNOP00000108960.1, ENSRNOT00000149825.1

  3. XM_006231817.5 → XP_006231879.1  rho guanine nucleotide exchange factor 28 isoform X3

    UniProtKB/TrEMBL
    A0A8L2UN35
    Related
    ENSRNOP00000101307.1, ENSRNOT00000123502.1
    Conserved Domains (4) summary
    smart00325
    Location:539 → 728
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00029
    Location:339 → 384
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14680
    Location:773 → 873
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    pfam00169
    Location:809 → 874
    PH; PH domain

RNA

  1. XR_010063623.1 RNA Sequence

  2. XR_010063622.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108542.1: Suppressed sequence

    Description
    NM_001108542.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C6P5.1 GenPept UniProtKB/Swiss-Prot:P0C6P5

Gene LinkOut

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