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INCENP inner centromere protein [ Homo sapiens (human) ]

Gene ID: 3619, updated on 5-Mar-2024

Summary

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Official Symbol
INCENPprovided by HGNC
Official Full Name
inner centromere proteinprovided by HGNC
Primary source
HGNC:HGNC:6058
See related
Ensembl:ENSG00000149503 MIM:604411; AllianceGenome:HGNC:6058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 6.2), esophagus (RPKM 5.2) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
11q12.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62124011..62153169)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62113566..62142731)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61891483..61920641)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2733 Neighboring gene NANOG hESC enhancer GRCh37_chr11:61870547-61871048 Neighboring gene uncharacterized LOC124902681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4812 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61891773-61892354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61895837-61896336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61897363-61897864 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:61912955-61913116 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:61942903-61943082 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61959742-61960242 Neighboring gene secretoglobin family 1D member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Targeting the Chromosomal Passenger Complex Subunit INCENP Induces Polyploidization, Apoptosis, and Senescence in Neuroblastoma. Sun M, et al. Cancer Res, 2019 Oct 1. PMID 31416840, Free PMC Article
  2. Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer. Kabisch M, et al. Carcinogenesis, 2015 Feb. PMID 25586992, Free PMC Article
  3. INCENP (inner centromere protein) is overexpressed in high grade non-Hodgkin B-cell lymphomas. Barbanis S, et al. Pathol Oncol Res, 2009 Mar. PMID 18752045
  4. INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow. Wheatley SP, et al. Exp Cell Res, 2001 Jan 15. PMID 11139336
  5. Role of nonhistone proteins in the chromosomal events of mitosis. Earnshaw WC, et al. FASEB J, 1994 Sep. PMID 8088460

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer.
    Title: High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer.
  2. Computational study of the potential impact of AURKC missense SNPs on AURKC-INCENP interaction and their correlation to macrozoospermia.
    Title: Computational study of the potential impact of AURKC missense SNPs on AURKC-INCENP interaction and their correlation to macrozoospermia.
  3. An ATM-Chk2-INCENP pathway activates the abscission checkpoint.
    Title: An ATM-Chk2-INCENP pathway activates the abscission checkpoint.
  4. lncRNA MIAT promotes esophageal squamous cell carcinoma progression by regulating miR-1301-3p/INCENP axis and interacting with SOX2.
    Title: lncRNA MIAT promotes esophageal squamous cell carcinoma progression by regulating miR-1301-3p/INCENP axis and interacting with SOX2.
  5. Switching of INCENP paralogs controls transitions in mitotic chromosomal passenger complex functions.
    Title: Switching of INCENP paralogs controls transitions in mitotic chromosomal passenger complex functions.
  6. Dysregulation of INCENP contributes to neuroblastoma tumorigenesis
    Title: Targeting the Chromosomal Passenger Complex Subunit INCENP Induces Polyploidization, Apoptosis, and Senescence in Neuroblastoma.
  7. In this study, we designed and synthesized 7-19 residues of inner centromere protein (INCENP)-derived small peptides (INC peptides) as novel survivin-targeting agents.
    Title: Discovery of inner centromere protein-derived small peptides for cancer imaging and treatment targeting survivin.
  8. Aurora-C interactions with members of the Chromosome Passenger Complex (CPC), Survivin and Inner Centromere Protein (INCENP) in reference to known Aurora-B interactions to understand the functional significance of Aurora-C overexpression in human cancer cells, is reported.
    Title: Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex.
  9. Data unveils a novel mechanism of PRMT1-mediated CPC regulation through methylation of INCENP.
    Title: PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.
  10. The data suggest that INCENP in the chromosomal passenger complex pathway contributes to estrogen receptor-negative breast cancer susceptibility in the European population.
    Title: Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
EBI GWAS Catalog
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates INCENP in HeLa cells within 12 hours of exposure PubMed
vpr HIV-1 Vpr interferes with the heterochromatin structure by displacing HP1-alpha and HP1-gamma proteins in interphase, which leads to relocalization of the centromere chromatin proteins Mis12, Sgo1, and INCENP/CPC after prophase PubMed
vpr AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31633, MGC111393

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular function activator activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle midzone assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic sister chromatid separation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in central element IEA
Inferred from Electronic Annotation
more info
  
located_in chromocenter IEA
Inferred from Electronic Annotation
more info
  
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromosome passenger complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral element IEA
Inferred from Electronic Annotation
more info
  
is_active_in meiotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
inner centromere protein
Names
binds and activates aurora-B and -C in vivo and in vitro
chromosomal passenger protein
inner centromere protein INCENP
inner centromere protein antigens 135/155kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040694.2 → NP_001035784.1  inner centromere protein isoform 1

    See identical proteins and their annotated locations for NP_001035784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP002793, AW839685, BC098576, BC111732, CV569756
    Consensus CDS
    CCDS44624.1
    UniProtKB/Swiss-Prot
    A8MQD2, Q5Y192, Q9NQS7
    Related
    ENSP00000378295.3, ENST00000394818.8
    Conserved Domains (2) summary
    pfam03941
    Location:831 → 882
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:6 → 41
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

  2. NM_020238.3 → NP_064623.2  inner centromere protein isoform 2

    See identical proteins and their annotated locations for NP_064623.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AP002793, AW839685, BC032678, BC098576, BC111732, CV569756
    Consensus CDS
    CCDS31582.1
    UniProtKB/Swiss-Prot
    Q9NQS7
    Related
    ENSP00000278849.4, ENST00000278849.4
    Conserved Domains (3) summary
    pfam03941
    Location:827 → 878
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:6 → 41
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    cl00583
    Location:520 → 613
    PhaG_MnhG_YufB; Na+/H+ antiporter subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62124011..62153169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544995.4 → XP_011543297.1  inner centromere protein isoform X1

    Conserved Domains (2) summary
    pfam03941
    Location:846 → 897
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:6 → 41
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

  2. XM_006718533.4 → XP_006718596.1  inner centromere protein isoform X5

    Conserved Domains (2) summary
    pfam03941
    Location:835 → 886
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:6 → 41
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

  3. XM_011544996.4 → XP_011543298.1  inner centromere protein isoform X3

    Conserved Domains (2) summary
    pfam03941
    Location:842 → 893
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:6 → 41
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

  4. XM_011544997.3 → XP_011543299.1  inner centromere protein isoform X2

    Conserved Domains (3) summary
    pfam03941
    Location:842 → 893
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:6 → 41
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    cl00583
    Location:520 → 613
    PhaG_MnhG_YufB; Na+/H+ antiporter subunit

  5. XM_047426886.1 → XP_047282842.1  inner centromere protein isoform X6

  6. XM_011544998.4 → XP_011543300.1  inner centromere protein isoform X4

    Conserved Domains (3) summary
    pfam03941
    Location:838 → 889
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:6 → 41
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    cl00583
    Location:520 → 613
    PhaG_MnhG_YufB; Na+/H+ antiporter subunit

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62113566..62142731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368673.1 → XP_054224648.1  inner centromere protein isoform X1

  2. XM_054368677.1 → XP_054224652.1  inner centromere protein isoform X5

  3. XM_054368675.1 → XP_054224650.1  inner centromere protein isoform X3

  4. XM_054368674.1 → XP_054224649.1  inner centromere protein isoform X2

  5. XM_054368678.1 → XP_054224653.1  inner centromere protein isoform X6

  6. XM_054368676.1 → XP_054224651.1  inner centromere protein isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NQS7.3 GenPept UniProtKB/Swiss-Prot:Q9NQS7

Gene LinkOut

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