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Atp11b ATPase phospholipid transporting 11B (putative) [ Rattus norvegicus (Norway rat) ]

Gene ID: 361929, updated on 10-Jul-2024

Summary

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Official Symbol
Atp11bprovided by RGD
Official Full Name
ATPase phospholipid transporting 11B (putative)provided by RGD
Primary source
RGD:1561719
See related
EnsemblRapid:ENSRNOG00000052116 AllianceGenome:RGD:1561719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; recycling endosome; and trans-Golgi network. Orthologous to human ATP11B (ATPase phospholipid transporting 11B (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 302.1), Spleen (RPKM 231.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atp11b in Genome Data Viewer
Location:
2q25
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (120513535..120619249)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (118585348..118691076)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (122337757..122445090)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene GABA type A receptor associated protein like 2, pseudogene 3 Neighboring gene RNA, U6 small nuclear 1158 Neighboring gene uncharacterized LOC134485899 Neighboring gene defective in cullin neddylation 1 domain containing 1 Neighboring gene methylcrotonyl-CoA carboxylase subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model. Quick S, et al. Acta Neuropathol, 2022 Aug. PMID 35635573, Free PMC Article
  2. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. Takatsu H, et al. J Biol Chem, 2011 Nov 4. PMID 21914794, Free PMC Article
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.
    Title: Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase IF
Names
ATPase, class VI, type 11B
probable phospholipid-transporting ATPase IF
NP_001413956.1
XP_038959541.1
XP_038959542.1
XP_038959543.1
XP_038959544.1
XP_063138130.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427027.1 → NP_001413956.1  phospholipid-transporting ATPase IF

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6A6I4, A0A8I6AJL0
    Related
    ENSRNOP00000099142.1, ENSRNOT00000168974.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    120513535..120619249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103615.2 → XP_038959543.1  phospholipid-transporting ATPase IF isoform X3

    UniProtKB/TrEMBL
    A0A8I6A6I4
    Related
    ENSRNOP00000093840.2, ENSRNOT00000117945.2
    Conserved Domains (2) summary
    cd02073
    Location:41 → 978
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    cl40732
    Location:959 → 1085
    AA_permease_2; Amino acid permease

  2. XM_039103614.2 → XP_038959542.1  phospholipid-transporting ATPase IF isoform X2

    UniProtKB/TrEMBL
    A0A8I6A6I4
    Related
    ENSRNOP00000088435.2, ENSRNOT00000116170.2
    Conserved Domains (2) summary
    cd02073
    Location:41 → 978
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    cl40732
    Location:959 → 1085
    AA_permease_2; Amino acid permease

  3. XM_039103613.2 → XP_038959541.1  phospholipid-transporting ATPase IF isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQT8
    Related
    ENSRNOP00000081047.2, ENSRNOT00000108850.2
    Conserved Domains (2) summary
    cd02073
    Location:41 → 978
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    cl40732
    Location:959 → 1085
    AA_permease_2; Amino acid permease

  4. XM_063282060.1 → XP_063138130.1  phospholipid-transporting ATPase IF isoform X4

    UniProtKB/TrEMBL
    A0A8I6ATU1

  5. XM_039103616.1 → XP_038959544.1  phospholipid-transporting ATPase IF isoform X5

    Conserved Domains (2) summary
    cl21460
    Location:1 → 616
    HAD_like; Haloacid Dehalogenase-like Hydrolases
    cl40732
    Location:597 → 723
    AA_permease_2; Amino acid permease
Nucleotide Protein Strain
Heading Accession and Version

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