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Pcdh10 protocadherin 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361943, updated on 2-Nov-2024

Summary

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Official Symbol
Pcdh10provided by RGD
Official Full Name
protocadherin 10provided by RGD
Primary source
RGD:1565811
See related
EnsemblRapid:ENSRNOG00000031974 AllianceGenome:RGD:1565811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565811
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be active in glutamatergic synapse and postsynaptic membrane. Orthologous to human PCDH10 (protocadherin 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 120.7) and Adrenal (RPKM 14.8) See more
Orthologs
human mouse all
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Genomic context

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See Pcdh10 in Genome Data Viewer
Location:
2q26
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (130553432..130619591)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (128617212..128683354)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (136992355..137017705)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal oxygenase 2, pseudogene 6 Neighboring gene uncharacterized LOC120100812 Neighboring gene RAN, member RAS oncogene family, pseudogene 3 Neighboring gene aldolase, fructose-bisphosphate A, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of a novel protocadherin, OL-protocadherin, in a subset of functional systems of the developing mouse brain. Hirano S, et al. J Neurosci, 1999 Feb 1. PMID 9920663, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protocadherin-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427768.1 → NP_001414697.1  protocadherin-10 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6GLZ0
    Related
    ENSRNOP00000078085.2, ENSRNOT00000099777.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    130553432..130619591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103633.2 → XP_038959561.1  protocadherin-10 isoform X1

    UniProtKB/TrEMBL
    D3ZRX7, F1M6B6
    Related
    ENSRNOP00000042694.4, ENSRNOT00000040187.6
    Conserved Domains (3) summary
    cd11304
    Location:254 → 354
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:19 → 101
    Cadherin_2; Cadherin-like
    pfam16492
    Location:713 → 838
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

  2. XM_039103634.2 → XP_038959562.1  protocadherin-10 isoform X2

    UniProtKB/TrEMBL
    A0A8I5YC59, A6KNH6
    Related
    ENSRNOP00000096196.2, ENSRNOT00000113130.2
    Conserved Domains (3) summary
    cd11304
    Location:254 → 354
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:19 → 101
    Cadherin_2; Cadherin-like
    pfam16492
    Location:713 → 838
    Cadherin_C_2; Cadherin cytoplasmic C-terminal
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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