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Elf2 E74 like ETS transcription factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361944, updated on 10-Oct-2024

Summary

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Official Symbol
Elf2provided by RGD
Official Full Name
E74 like ETS transcription factor 2provided by RGD
Primary source
RGD:1310585
See related
EnsemblRapid:ENSRNOG00000010815 AllianceGenome:RGD:1310585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Orthologous to human ELF2 (E74 like ETS transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 97.0), Testes (RPKM 91.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Elf2 in Genome Data Viewer
Location:
2q26
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (137445787..137536512, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (135292291..135385942, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (140310374..140399312, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485733 Neighboring gene nocturnin Neighboring gene transfer RNA proline (anticodon UGG) 2 Neighboring gene transfer RNA proline (anticodon AGG) 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Colocalization of oxytocin and phosphorylated form of elongation factor 2 in the rat hypothalamus. Fujisawa T, et al. Acta Med Okayama, 2007 Jun. PMID 17593952
  2. Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. Grønli J, et al. Behav Brain Res, 2012 Dec 1. PMID 22917528
  3. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. Oettgen P, et al. Mol Cell Biol, 1996 Sep. PMID 8756667, Free PMC Article
  4. Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. Cho JY, et al. J Biol Chem, 2004 May 7. PMID 14970218
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The eEF2 phosphorylation was elevated in all brain regions after sleep deprivation
    Title: Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation.
  2. Oxt is colocalized with the phosphorylated form of Elf2 in the hypothalamus.
    Title: Colocalization of oxytocin and phosphorylated form of elongation factor 2 in the rat hypothalamus.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ETS-related transcription factor Elf-2
Names
E74-like factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012181.2 → NP_001012181.1  ETS-related transcription factor Elf-2 isoform 2

    See identical proteins and their annotated locations for NP_001012181.1

    Status: VALIDATED

    Source sequence(s)
    BC083585, BC083598, JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6AGL8, A0A9K3Y6V8, G3V7H5, Q5XIS3
    Related
    ENSRNOP00000086563.1, ENSRNOT00000102166.2
    Conserved Domains (2) summary
    pfam00178
    Location:138 → 217
    Ets; Ets-domain
    pfam12310
    Location:20 → 48
    Elf-1_N; Transcription factor protein N terminal

  2. NM_001033909.1 → NP_001029081.1  ETS-related transcription factor Elf-2 isoform 1

    See identical proteins and their annotated locations for NP_001029081.1

    Status: VALIDATED

    Source sequence(s)
    BC083585
    UniProtKB/TrEMBL
    A0A8I6AGL8, A6JV53, F7FA98, Q5XIT5
    Conserved Domains (3) summary
    pfam05109
    Location:349 → 528
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00178
    Location:209 → 289
    Ets; Ets-domain
    pfam12310
    Location:3 → 108
    Elf-1_N; Transcription factor protein N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    137445787..137536512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282069.1 → XP_063138139.1  ETS-related transcription factor Elf-2 isoform X2

  2. XM_006232325.5 → XP_006232387.1  ETS-related transcription factor Elf-2 isoform X1

    See identical proteins and their annotated locations for XP_006232387.1

    UniProtKB/TrEMBL
    A0A8I6AGL8, A6JV53, F7FA98, Q5XIT5
    Conserved Domains (3) summary
    pfam05109
    Location:349 → 528
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00178
    Location:209 → 289
    Ets; Ets-domain
    pfam12310
    Location:3 → 108
    Elf-1_N; Transcription factor protein N terminal

  3. XM_063282068.1 → XP_063138138.1  ETS-related transcription factor Elf-2 isoform X1

    UniProtKB/TrEMBL
    A6JV53, F7FA98, Q5XIT5

  4. XM_063282070.1 → XP_063138140.1  ETS-related transcription factor Elf-2 isoform X2

  5. XM_006232329.4 → XP_006232391.1  ETS-related transcription factor Elf-2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AGL8
    Related
    ENSRNOP00000090124.2, ENSRNOT00000110678.2
    Conserved Domains (1) summary
    pfam00178
    Location:94 → 173
    Ets; Ets-domain

  6. XM_006232328.4 → XP_006232390.1  ETS-related transcription factor Elf-2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AGL8
    Conserved Domains (1) summary
    pfam00178
    Location:106 → 185
    Ets; Ets-domain

  7. XM_039102601.2 → XP_038958529.1  ETS-related transcription factor Elf-2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AGL8
    Conserved Domains (2) summary
    pfam05109
    Location:214 → 393
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00178
    Location:74 → 154
    Ets; Ets-domain

  8. XM_039102600.2 → XP_038958528.1  ETS-related transcription factor Elf-2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AGL8
    Conserved Domains (2) summary
    pfam05109
    Location:214 → 393
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00178
    Location:74 → 154
    Ets; Ets-domain

  9. XM_006232327.5 → XP_006232389.1  ETS-related transcription factor Elf-2 isoform X3

    See identical proteins and their annotated locations for XP_006232389.1

    UniProtKB/TrEMBL
    A0A8I6A6H4, A6JV55
    Related
    ENSRNOP00000015067.6, ENSRNOT00000015067.9
    Conserved Domains (2) summary
    pfam00178
    Location:150 → 229
    Ets; Ets-domain
    pfam12310
    Location:20 → 48
    Elf-1_N; Transcription factor protein N terminal
Nucleotide Protein Strain
Heading Accession and Version

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