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Ubap2l ubiquitin associated protein 2-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 361984, updated on 2-Nov-2024

Summary

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Official Symbol
Ubap2lprovided by RGD
Official Full Name
ubiquitin associated protein 2-likeprovided by RGD
Primary source
RGD:1308707
See related
EnsemblRapid:ENSRNOG00000017990 AllianceGenome:RGD:1308707
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
EP1; Atp8b2
Summary
Predicted to be involved in several processes, including binding activity of sperm to zona pellucida; hematopoietic stem cell homeostasis; and positive regulation of stress granule assembly. Predicted to be part of PcG protein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBAP2L (ubiquitin associated protein 2 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 147.0), Adrenal (RPKM 127.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ubap2l in Genome Data Viewer
Location:
2q34
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177736378..177791746, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175438703..175494085, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189334341..189400334, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485642 Neighboring gene uncharacterized LOC103691621 Neighboring gene HCLS1 associated protein X-1 Neighboring gene NS5A transactivated protein 4 Neighboring gene cilia and flagella associated protein 141

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. Bordeleau ME, et al. Blood, 2014 Oct 9. PMID 25185265, Free PMC Article
  2. Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION. Ansari IU, et al. J Biol Chem, 2015 Sep 18. PMID 26240149, Free PMC Article
  3. Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system. Naz RK, et al. J Reprod Immunol, 2010 Jan. PMID 19945174, Free PMC Article
  4. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. Wang YL, et al. J Biol Chem, 2008 Dec 5. PMID 18838386, Free PMC Article
  5. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the predominant P4 ATPases in pure pancreatic beta cells and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A. ATP8B1 and CDC50A were highly concentrated in ISG
    Title: Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
  
involved_in hematopoietic stem cell homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-associated protein 2-like
Names
Atpase, class I, type 8B, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024798.2 → NP_001019969.2  ubiquitin-associated protein 2-like

    See identical proteins and their annotated locations for NP_001019969.2

    Status: PROVISIONAL

    Source sequence(s)
    CH473976
    UniProtKB/TrEMBL
    A0A8I6ARP3, A6J6I9, E9PTR4
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:516 → 543
    DUF3697; Ubiquitin-associated protein 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    177736378..177791746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282147.1 → XP_063138217.1  ubiquitin-associated protein 2-like isoform X24

  2. XM_063282140.1 → XP_063138210.1  ubiquitin-associated protein 2-like isoform X18

  3. XM_063282157.1 → XP_063138227.1  ubiquitin-associated protein 2-like isoform X33

    UniProtKB/TrEMBL
    A0A0G2JYC6, A6J6I8

  4. XM_063282155.1 → XP_063138225.1  ubiquitin-associated protein 2-like isoform X29

  5. XM_063282150.1 → XP_063138220.1  ubiquitin-associated protein 2-like isoform X26

  6. XM_063282148.1 → XP_063138218.1  ubiquitin-associated protein 2-like isoform X25

  7. XM_063282156.1 → XP_063138226.1  ubiquitin-associated protein 2-like isoform X31

  8. XM_063282149.1 → XP_063138219.1  ubiquitin-associated protein 2-like isoform X26

  9. XM_063282146.1 → XP_063138216.1  ubiquitin-associated protein 2-like isoform X24

  10. XM_063282142.1 → XP_063138212.1  ubiquitin-associated protein 2-like isoform X21

  11. XM_039102685.2 → XP_038958613.1  ubiquitin-associated protein 2-like isoform X34

    UniProtKB/TrEMBL
    A0A8I6ARP3
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496 → 523
    DUF3697; Ubiquitin-associated protein 2

  12. XM_039102681.2 → XP_038958609.1  ubiquitin-associated protein 2-like isoform X30

    UniProtKB/TrEMBL
    A0A8I6ARP3
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496 → 523
    DUF3697; Ubiquitin-associated protein 2

  13. XM_039102683.2 → XP_038958611.1  ubiquitin-associated protein 2-like isoform X32

    UniProtKB/TrEMBL
    A0A8I6ARP3
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507 → 534
    DUF3697; Ubiquitin-associated protein 2

  14. XM_063282141.1 → XP_063138211.1  ubiquitin-associated protein 2-like isoform X19

  15. XM_039102667.2 → XP_038958595.1  ubiquitin-associated protein 2-like isoform X8

    UniProtKB/TrEMBL
    A0A8I6ARP3
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:532 → 559
    DUF3697; Ubiquitin-associated protein 2

  16. XM_063282151.1 → XP_063138221.1  ubiquitin-associated protein 2-like isoform X27

    UniProtKB/TrEMBL
    A0A8I6ACU2

  17. XM_063282152.1 → XP_063138222.1  ubiquitin-associated protein 2-like isoform X28

  18. XM_063282138.1 → XP_063138208.1  ubiquitin-associated protein 2-like isoform X15

  19. XM_063282137.1 → XP_063138207.1  ubiquitin-associated protein 2-like isoform X14

  20. XM_063282136.1 → XP_063138206.1  ubiquitin-associated protein 2-like isoform X13

    UniProtKB/TrEMBL
    A0A8I5ZUK2

  21. XM_063282145.1 → XP_063138215.1  ubiquitin-associated protein 2-like isoform X22

  22. XM_063282133.1 → XP_063138203.1  ubiquitin-associated protein 2-like isoform X10

  23. XM_063282132.1 → XP_063138202.1  ubiquitin-associated protein 2-like isoform X9

  24. XM_063282130.1 → XP_063138200.1  ubiquitin-associated protein 2-like isoform X6

    Related
    ENSRNOP00000082678.2, ENSRNOT00000117564.2

  25. XM_063282131.1 → XP_063138201.1  ubiquitin-associated protein 2-like isoform X9

  26. XM_063282144.1 → XP_063138214.1  ubiquitin-associated protein 2-like isoform X22

  27. XM_063282134.1 → XP_063138204.1  ubiquitin-associated protein 2-like isoform X11

  28. XM_063282129.1 → XP_063138199.1  ubiquitin-associated protein 2-like isoform X6

  29. XM_039102674.2 → XP_038958602.1  ubiquitin-associated protein 2-like isoform X17

    UniProtKB/TrEMBL
    A0A8I6ARP3
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496 → 523
    DUF3697; Ubiquitin-associated protein 2

  30. XM_063282139.1 → XP_063138209.1  ubiquitin-associated protein 2-like isoform X16

    Related
    ENSRNOP00000091988.2, ENSRNOT00000116567.2

  31. XM_039102664.2 → XP_038958592.1  ubiquitin-associated protein 2-like isoform X5

    UniProtKB/TrEMBL
    A0A8I6ARP3
    Related
    ENSRNOP00000096813.1, ENSRNOT00000101660.2
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:516 → 543
    DUF3697; Ubiquitin-associated protein 2

  32. XM_039102663.2 → XP_038958591.1  ubiquitin-associated protein 2-like isoform X4

    UniProtKB/TrEMBL
    A0A8I6ARP3
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:521 → 548
    DUF3697; Ubiquitin-associated protein 2

  33. XM_039102677.2 → XP_038958605.1  ubiquitin-associated protein 2-like isoform X23

    UniProtKB/TrEMBL
    A0A8I6ARP3
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507 → 534
    DUF3697; Ubiquitin-associated protein 2

  34. XM_063282135.1 → XP_063138205.1  ubiquitin-associated protein 2-like isoform X12

  35. XM_063282128.1 → XP_063138198.1  ubiquitin-associated protein 2-like isoform X3

  36. XM_039102666.2 → XP_038958594.1  ubiquitin-associated protein 2-like isoform X7

    UniProtKB/TrEMBL
    A0A8I6ARP3
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:532 → 559
    DUF3697; Ubiquitin-associated protein 2

  37. XM_039102661.2 → XP_038958589.1  ubiquitin-associated protein 2-like isoform X2

    UniProtKB/TrEMBL
    A0A8I6ARP3
    Conserved Domains (2) summary
    cd14277
    Location:50 → 87
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:532 → 559
    DUF3697; Ubiquitin-associated protein 2

  38. XM_063282127.1 → XP_063138197.1  ubiquitin-associated protein 2-like isoform X1

  39. XM_039102675.2 → XP_038958603.1  ubiquitin-associated protein 2-like isoform X20

    UniProtKB/TrEMBL
    A0A8I6ARP3
    Conserved Domains (2) summary
    cd14277
    Location:10 → 47
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:492 → 519
    DUF3697; Ubiquitin-associated protein 2

  40. XM_039102686.2 → XP_038958614.2  ubiquitin-associated protein 2-like isoform X37

  41. XM_063282159.1 → XP_063138229.1  ubiquitin-associated protein 2-like isoform X36

    UniProtKB/TrEMBL
    A0A8I5ZWV5
    Related
    ENSRNOP00000084271.1, ENSRNOT00000112048.2

  42. XM_063282165.1 → XP_063138235.1  ubiquitin-associated protein 2-like isoform X40

  43. XM_063282162.1 → XP_063138232.1  ubiquitin-associated protein 2-like isoform X38

  44. XM_063282163.1 → XP_063138233.1  ubiquitin-associated protein 2-like isoform X39

  45. XM_063282158.1 → XP_063138228.1  ubiquitin-associated protein 2-like isoform X35

  46. XM_063282161.1 → XP_063138231.1  ubiquitin-associated protein 2-like isoform X38

  47. XM_063282160.1 → XP_063138230.1  ubiquitin-associated protein 2-like isoform X37

  48. XM_063282164.1 → XP_063138234.1  ubiquitin-associated protein 2-like isoform X40

  49. XM_063282166.1 → XP_063138236.1  ubiquitin-associated protein 2-like isoform X41

    UniProtKB/TrEMBL
    Q4V8A7
Nucleotide Protein Strain
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