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S100a16 S100 calcium binding protein A16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361991, updated on 5-Mar-2024

Summary

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Official Symbol
S100a16provided by RGD
Official Full Name
S100 calcium binding protein A16provided by RGD
Primary source
RGD:1306770
See related
Ensembl:ENSRNOG00000012053 AllianceGenome:RGD:1306770
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity; calcium-dependent protein binding activity; and protein homodimerization activity. Predicted to act upstream of or within response to calcium ion. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be active in cytoplasm; extracellular space; and nucleus. Orthologous to human S100A16 (S100 calcium binding protein A16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 505.4), Heart (RPKM 349.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See S100a16 in Genome Data Viewer
Location:
2q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (178313986..178319696)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (176016405..176022117)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189923140..189928850)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A13 Neighboring gene S100 calcium binding protein A14 Neighboring gene U6 spliceosomal RNA Neighboring gene S100 calcium binding protein A3 Neighboring gene MIER family member 3, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Estrogen suppresses adipogenesis by inhibiting S100A16 expression. Zhang R, et al. J Mol Endocrinol, 2014 Jun. PMID 24501224, Free PMC Article
  2. S100A16 mediation of weight gain attenuation induced by dietary calcium. Zhang R, et al. Metabolism, 2012 Feb. PMID 21871643
  3. S100A16, a novel calcium-binding protein of the EF-hand superfamily. Sturchler E, et al. J Biol Chem, 2006 Dec 15. PMID 17030513
  4. Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection. Fornander L, et al. Proteomics Clin Appl, 2011 Oct. PMID 21805676
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Estrogen suppressed adipogenesis by inhibiting S100A16 expression.
    Title: Estrogen suppresses adipogenesis by inhibiting S100A16 expression.
  2. High-calcium diets may lead to nuclear exclusion of S100A16, which results in the inhibition of adipogenesis and enhanced insulin sensitivity.
    Title: S100A16 mediation of weight gain attenuation induced by dietary calcium.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein S100-A16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108557.2 → NP_001102027.1  protein S100-A16

    See identical proteins and their annotated locations for NP_001102027.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158598
    UniProtKB/TrEMBL
    A6J6N9, A6J6P2, B0BMX3
    Related
    ENSRNOP00000016499.4, ENSRNOT00000016499.8
    Conserved Domains (1) summary
    cd05022
    Location:6 → 94
    S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    178313986..178319696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102692.2 → XP_038958620.1  protein S100-A16 isoform X1

    UniProtKB/TrEMBL
    A6J6N9, A6J6P2, B0BMX3
    Conserved Domains (1) summary
    cd05022
    Location:6 → 94
    S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...

  2. XM_006232718.4 → XP_006232780.1  protein S100-A16 isoform X1

    See identical proteins and their annotated locations for XP_006232780.1

    UniProtKB/TrEMBL
    A6J6N9, A6J6P2, B0BMX3
    Conserved Domains (1) summary
    cd05022
    Location:6 → 94
    S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...

  3. XM_006232717.5 → XP_006232779.1  protein S100-A16 isoform X1

    See identical proteins and their annotated locations for XP_006232779.1

    UniProtKB/TrEMBL
    A6J6N9, A6J6P2, B0BMX3
    Conserved Domains (1) summary
    cd05022
    Location:6 → 94
    S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
Nucleotide Protein Strain
Heading Accession and Version

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