U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362045, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Lamtor3provided by RGD
Official Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3provided by RGD
Primary source
RGD:1307133
See related
EnsemblRapid:ENSRNOG00000088035 AllianceGenome:RGD:1307133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MP1; Mapksp1; Map2k1ip1
Summary
Predicted to enable kinase activator activity. Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in cellular response to amino acid stimulus; positive regulation of TORC1 signaling; and protein localization. Predicted to act upstream of or within positive regulation of MAPK cascade and protein localization to cell junction. Predicted to be located in late endosome membrane. Predicted to be part of FNIP-folliculin RagC/D GAP and Ragulator complex. Predicted to be active in late endosome and lysosomal membrane. Orthologous to human LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 185.1), Muscle (RPKM 138.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Lamtor3 in Genome Data Viewer
Location:
2q43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (229084795..229097028)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (226411389..226423612)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (243160821..243173057)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene H2A.Z variant histone 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member B14 Neighboring gene dual adaptor of phosphotyrosine and 3-phosphoinositides 1 Neighboring gene uncharacterized LOC120100950 Neighboring gene uncharacterized LOC120100951

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. Pullikuth A, et al. Mol Cell Biol, 2005 Jun. PMID 15923628, Free PMC Article
  2. Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Kurzbauer R, et al. Proc Natl Acad Sci U S A, 2004 Jul 27. PMID 15263099, Free PMC Article
  3. The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. Nada S, et al. EMBO J, 2009 Mar 4. PMID 19177150, Free PMC Article
  4. Regulation of mTORC1 by amino acids. Bar-Peled L, et al. Trends Cell Biol, 2014 Jul. PMID 24698685, Free PMC Article
  5. The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration. Schiefermeier N, et al. J Cell Biol, 2014 May 26. PMID 24841562, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC106009

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to cell junction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein localization to cell junction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP IEA
Inferred from Electronic Annotation
more info
  
part_of FNIP-folliculin RagC/D GAP ISO
Inferred from Sequence Orthology
more info
  
part_of Ragulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ragulator complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ragulator complex ISO
Inferred from Sequence Orthology
more info
  
part_of Ragulator complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ragulator complex protein LAMTOR3
Names
MEK partner 1
late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
mitogen-activated protein kinase kinase 1-interacting protein 1
mitogen-activated protein kinase scaffold protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008375.1 → NP_001008376.1  ragulator complex protein LAMTOR3

    See identical proteins and their annotated locations for NP_001008376.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086353
    UniProtKB/Swiss-Prot
    Q5U204
    UniProtKB/TrEMBL
    A0A8L2Q6U4, A6HW13
    Related
    ENSRNOP00000105487.1, ENSRNOT00000128241.1
    Conserved Domains (1) summary
    pfam08923
    Location:3 → 121
    MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting

  2. NM_001429142.1 → NP_001416071.1  ragulator complex protein LAMTOR3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q5U204
    UniProtKB/TrEMBL
    A6HW13

  3. NM_001429143.1 → NP_001416072.1  ragulator complex protein LAMTOR3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q5U204
    UniProtKB/TrEMBL
    A6HW13

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    229084795..229097028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282225.1 → XP_063138295.1  ragulator complex protein LAMTOR3 isoform X1

  2. XM_006233383.5 → XP_006233445.1  ragulator complex protein LAMTOR3 isoform X2

    Conserved Domains (1) summary
    pfam08923
    Location:3 → 121
    MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting

  3. XM_006233385.5 → XP_006233447.1  ragulator complex protein LAMTOR3 isoform X2

    Conserved Domains (1) summary
    pfam08923
    Location:3 → 121
    MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting

  4. XM_063282224.1 → XP_063138294.1  ragulator complex protein LAMTOR3 isoform X1

  5. XM_063282222.1 → XP_063138292.1  ragulator complex protein LAMTOR3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U204.1 GenPept UniProtKB/Swiss-Prot:Q5U204

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous