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Ubac1 UBA domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362087, updated on 2-Nov-2024

Summary

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Official Symbol
Ubac1provided by RGD
Official Full Name
UBA domain containing 1provided by RGD
Primary source
RGD:1359542
See related
EnsemblRapid:ENSRNOG00000017983 AllianceGenome:RGD:1359542
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ubadc1
Summary
Predicted to enable polyubiquitin modification-dependent protein binding activity and proteasome binding activity. Predicted to be involved in protein maturation and protein ubiquitination. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of ubiquitin ligase complex. Orthologous to human UBAC1 (UBA domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 749.2), Heart (RPKM 288.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ubac1 in Genome Data Viewer
Location:
3p13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (29223582..29246216, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8825444..8848055, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (3453396..3476242, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene calmodulin regulated spectrin-associated protein 1 Neighboring gene ribosomal protein L8, pseudogene 7 Neighboring gene PIH1 domain containing 1, pseudogene 1 Neighboring gene uncharacterized LOC120101509 Neighboring gene NACC family member 2 Neighboring gene uncharacterized LOC103691752

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Kamura T, et al. Nat Cell Biol, 2004 Dec. PMID 15531880
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94349

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables proteasome binding IEA
Inferred from Electronic Annotation
more info
  
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
  
enables proteasome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-associated domain-containing protein 1
Names
E3 ubiquitin-protein ligase subunit KPC2
UBA domain-containing protein 1
kip1 ubiquitination-promoting complex protein 2
ubiquitin associated domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007742.1 → NP_001007743.1  ubiquitin-associated domain-containing protein 1

    See identical proteins and their annotated locations for NP_001007743.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083603
    UniProtKB/Swiss-Prot
    Q5XIR9
    UniProtKB/TrEMBL
    A0A8I6GI40, A6JTB9
    Related
    ENSRNOP00000024352.3, ENSRNOT00000024352.6
    Conserved Domains (4) summary
    smart00727
    Location:357 → 396
    STI1; Heat shock chaperonin-binding motif
    cd14303
    Location:195 → 232
    UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cd14304
    Location:294 → 331
    UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cd17066
    Location:9 → 95
    Ubl_KPC2; ubiquitin-like (Ubl) domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    29223582..29246216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233689.3 → XP_006233751.1  ubiquitin-associated domain-containing protein 1 isoform X2

    Related
    ENSRNOP00000109139.1, ENSRNOT00000167041.1
    Conserved Domains (2) summary
    cd14303
    Location:195 → 232
    UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cl21463
    Location:294 → 325
    UBA_like_SF; UBA domain-like superfamily

  2. XM_039105357.1 → XP_038961285.1  ubiquitin-associated domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GI40
    Related
    ENSRNOP00000106592.1, ENSRNOT00000135533.1
    Conserved Domains (3) summary
    cd14303
    Location:195 → 232
    UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cd14304
    Location:294 → 331
    UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cd17066
    Location:9 → 95
    Ubl_KPC2; ubiquitin-like (Ubl) domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIR9.1 GenPept UniProtKB/Swiss-Prot:Q5XIR9

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