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Ptrh1 peptidyl-tRNA hydrolase 1 homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 362113, updated on 2-Nov-2024

Summary

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Official Symbol
Ptrh1provided by RGD
Official Full Name
peptidyl-tRNA hydrolase 1 homologprovided by RGD
Primary source
RGD:1310165
See related
EnsemblRapid:ENSRNOG00000049034 AllianceGenome:RGD:1310165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310165
Summary
Predicted to enable aminoacyl-tRNA hydrolase activity. Predicted to be involved in rescue of stalled ribosome. Predicted to be located in mitochondrion. Orthologous to human PTRH1 (peptidyl-tRNA hydrolase 1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 54.9), Lung (RPKM 47.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptrh1 in Genome Data Viewer
Location:
3p11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36462575..36475605)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (16064867..16071098)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11811303..11817007)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 3C Neighboring gene RNA, U6 small nuclear 899 Neighboring gene torsin family 2, member A Neighboring gene tetratricopeptide repeat domain 16 Neighboring gene cilia and flagella associated protein 157 Neighboring gene syntaxin binding protein 1 Neighboring gene uncharacterized LOC134486073 Neighboring gene niban apoptosis regulator 2 Neighboring gene leucine rich repeat and sterile alpha motif containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminoacyl-tRNA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacyl-tRNA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
peptidyl-tRNA hydrolase
Names
probable peptidyl-tRNA hydrolase
XP_038962111.2
XP_063140142.1
XP_063140144.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399255.2 → NP_001386184.2  peptidyl-tRNA hydrolase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JU87
    Related
    ENSRNOP00000032989.6, ENSRNOT00000039151.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    36462575..36475605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284072.1 → XP_063140142.1  peptidyl-tRNA hydrolase isoform X1

  2. XM_039106183.2 → XP_038962111.2  peptidyl-tRNA hydrolase isoform X2

  3. XM_063284074.1 → XP_063140144.1  peptidyl-tRNA hydrolase isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108580.1: Suppressed sequence

    Description
    NM_001108580.1: This RefSeq was suppressed temporarily pending review of supporting evidence.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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