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C5l1 complement C5 like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362120, updated on 2-Nov-2024

Summary

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Official Symbol
C5l1provided by RGD
Official Full Name
complement C5 like 1provided by RGD
Primary source
RGD:1308742
See related
EnsemblRapid:ENSRNOG00000022033 AllianceGenome:RGD:1308742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308742
Summary
Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in complement activation, alternative pathway; complement activation, classical pathway; and inflammatory response. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 173.5) See more
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Genomic context

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See C5l1 in Genome Data Viewer
Location:
3p11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (38799165..38818443, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (18401716..18420064, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (14273552..14291401, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene complement C5 Neighboring gene uncharacterized LOC134486354 Neighboring gene centriolin Neighboring gene RAB14, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
complement C5; complement C5-like; hemolytic complement-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430477.1 → NP_001417406.1  hemolytic complement-like precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    38799165..38818443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106218.2 → XP_038962146.1  complement C5-like isoform X2

    Conserved Domains (3) summary
    cd00017
    Location:190 → 243
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    pfam17790
    Location:28 → 99
    MG1; Macroglobulin domain MG1
    cl19929
    Location:90 → 149
    A2M_N; MG2 domain

  2. XM_017592127.3 → XP_017447616.1  complement C5-like isoform X1

  3. XM_017592129.3 → XP_017447618.2  complement C5-like isoform X9

    UniProtKB/TrEMBL
    A6JUE4
    Related
    ENSRNOP00000082846.2, ENSRNOT00000035829.7
    Conserved Domains (3) summary
    cd00017
    Location:269 → 322
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    pfam01835
    Location:134 → 228
    A2M_N; MG2 domain
    pfam17790
    Location:32 → 128
    MG1; Macroglobulin domain MG1

  4. XM_063285242.1 → XP_063141312.1  complement C5-like isoform X6

  5. XM_039106222.1 → XP_038962150.1  complement C5-like isoform X5

    Conserved Domains (2) summary
    pfam17790
    Location:32 → 100
    MG1; Macroglobulin domain MG1
    cl19929
    Location:91 → 150
    A2M_N; MG2 domain

  6. XM_039106220.1 → XP_038962148.1  complement C5-like isoform X3

    Conserved Domains (2) summary
    pfam17790
    Location:32 → 100
    MG1; Macroglobulin domain MG1
    cl19929
    Location:91 → 150
    A2M_N; MG2 domain

  7. XM_039106225.1 → XP_038962153.1  complement C5 isoform X7

    Conserved Domains (1) summary
    pfam17790
    Location:32 → 128
    MG1; Macroglobulin domain MG1

  8. XM_063285243.1 → XP_063141313.1  complement C5 isoform X8

  9. XM_039106221.1 → XP_038962149.1  complement C5 isoform X4

    UniProtKB/TrEMBL
    A6JUE5
    Conserved Domains (2) summary
    pfam17790
    Location:32 → 128
    MG1; Macroglobulin domain MG1
    cl19929
    Location:134 → 169
    A2M_N; MG2 domain

RNA

  1. XR_005502099.1 RNA Sequence

  2. XR_010065163.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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