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Zdhhc5 zinc finger DHHC-type palmitoyltransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362156, updated on 2-Nov-2024

Summary

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Official Symbol
Zdhhc5provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 5provided by RGD
Primary source
RGD:1589737
See related
EnsemblRapid:ENSRNOG00000006832 AllianceGenome:RGD:1589737
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DHHC-5
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in dendrite. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization, intracellular component. Orthologous to human ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 196.5), Kidney (RPKM 193.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zdhhc5 in Genome Data Viewer
Location:
3q24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90178734..90206889, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69772037..69800142, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72090526..72118406, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene selenoprotein H Neighboring gene thioredoxin-related transmembrane protein 2 Neighboring gene mediator complex subunit 19 Neighboring gene uncharacterized LOC120101590 Neighboring gene cleavage factor polyribonucleotide kinase subunit 1 Neighboring gene yippee-like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway. Collura KM, et al. J Biol Chem, 2020 Nov 13. PMID 32958558, Free PMC Article
  2. Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5. Brigidi GS, et al. Nat Commun, 2015 Sep 3. PMID 26334723, Free PMC Article
  3. S-acylated Golga7b stabilises DHHC5 at the plasma membrane to regulate cell adhesion. Woodley KT, et al. EMBO Rep, 2019 Oct 4. PMID 31402609, Free PMC Article
  4. Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking. Thomas GM, et al. Neuron, 2012 Feb 9. PMID 22325201, Free PMC Article
  5. Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. Kokkola T, et al. FEBS Lett, 2011 Sep 2. PMID 21820437

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway.
    Title: The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway.
  2. DHHC5, to palmitoylate substrates in an activity-dependent manner is dependent on changes in its subcellular localization.
    Title: Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5.
  3. this study identified the first neuronal DHHC5/8 substrate, define novel mechanisms controlling palmitoylation specificity, and suggest further links between dysregulated palmitoylation and neuropathological conditions.
    Title: Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of pattern recognition receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of pyroptotic inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of pyroptotic inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein palmitoylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic specialization, intracellular component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization, intracellular component IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
palmitoyltransferase ZDHHC5
Names
membrane-associated DHHC5 zinc finger protein
probable palmitoyltransferase ZDHHC5
zinc finger DHHC domain-containing protein 5
zinc finger, DHHC domain containing 5
zinc finger, DHHC-type containing 5
NP_001034427.1
XP_017447385.1
XP_017447386.1
XP_017447387.1
XP_038961338.1
XP_063140208.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039338.1 → NP_001034427.1  palmitoyltransferase ZDHHC5

    See identical proteins and their annotated locations for NP_001034427.1

    Status: PROVISIONAL

    Source sequence(s)
    AY871203
    UniProtKB/Swiss-Prot
    Q2THW7
    UniProtKB/TrEMBL
    A6HMR0
    Related
    ENSRNOP00000009708.4, ENSRNOT00000009708.7
    Conserved Domains (1) summary
    pfam01529
    Location:99 → 224
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    90178734..90206889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591896.3 → XP_017447385.1  palmitoyltransferase ZDHHC5 isoform X1

    UniProtKB/Swiss-Prot
    Q2THW7
    UniProtKB/TrEMBL
    A6HMR0
    Conserved Domains (1) summary
    pfam01529
    Location:99 → 224
    zf-DHHC; DHHC palmitoyltransferase

  2. XM_017591898.3 → XP_017447387.1  palmitoyltransferase ZDHHC5 isoform X1

    UniProtKB/Swiss-Prot
    Q2THW7
    UniProtKB/TrEMBL
    A6HMR0
    Conserved Domains (1) summary
    pfam01529
    Location:99 → 224
    zf-DHHC; DHHC palmitoyltransferase

  3. XM_017591897.3 → XP_017447386.1  palmitoyltransferase ZDHHC5 isoform X1

    UniProtKB/Swiss-Prot
    Q2THW7
    UniProtKB/TrEMBL
    A6HMR0
    Conserved Domains (1) summary
    pfam01529
    Location:99 → 224
    zf-DHHC; DHHC palmitoyltransferase

  4. XM_039105410.2 → XP_038961338.1  palmitoyltransferase ZDHHC5 isoform X2

    UniProtKB/TrEMBL
    A6HMR0
    Conserved Domains (1) summary
    pfam01529
    Location:46 → 171
    DHHC; DHHC palmitoyltransferase

  5. XM_063284138.1 → XP_063140208.1  palmitoyltransferase ZDHHC5 isoform X1

    UniProtKB/Swiss-Prot
    Q2THW7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2THW7.1 GenPept UniProtKB/Swiss-Prot:Q2THW7

Gene LinkOut

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