Procr protein C receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Procrprovided by RGD
Official Full Name: protein C receptorprovided by RGD
Primary source: RGD:1305991
See related: EnsemblRapid:ENSRNOG00000019330 AllianceGenome:RGD:1305991
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EPCR
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in negative regulation of coagulation. Located in extracellular space and perinuclear region of cytoplasm. Biomarker of acute kidney failure and carotid stenosis. Orthologous to human PROCR (protein C receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 57.9), Lung (RPKM 42.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (164714727..164718994)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (144254596..144258863)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (151285321..151289581)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of thrombomodulin and endothelial protein C receptor mRNAs of rats after paraquat intoxication is increased, and can significantly be decreased after administered with Na-DMPS.
Title: [Expression of thrombomodulin, endothelial protein C receptor in lung tissue of acute paraquat poisoned rats and intervention of sodium dimercaptopropane sulfonate].
PROCR is a novel, NFAT-dependent gene that may be implicated in vascular restenosis and consequent inward remodeling.
Title: Genome-wide microarray analyses identify the protein C receptor as a novel calcineurin/nuclear factor of activated T cells-dependent gene in vascular smooth muscle cell phenotypic modulation.
Activated protein C could augment the anti-coagulation and anti-inflammatory activity by up-regulating endothelial cell protein C receptor and thrombomodulin expression, thus attenuating the severity of severe acute pancreatis.
Title: Activated protein C improves the severity of severe acute pancreatitis via up-regulating the expressions of endothelial cell protein C receptor and thrombomodulin.

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General gene information

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Markers

BF401256 (e-PCR)
- UniSTS:245446

AI072354 (e-PCR)
- UniSTS:244958

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of coagulation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: endothelial protein C receptor

Names: APC receptor; activated protein C receptor; endothelial cell protein C receptor; protein C receptor, endothelial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.