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Vstm2l V-set and transmembrane domain containing 2 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 362255, updated on 13-Jul-2024

Summary

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Official Symbol
Vstm2lprovided by RGD
Official Full Name
V-set and transmembrane domain containing 2 likeprovided by RGD
Primary source
RGD:1305725
See related
AllianceGenome:RGD:1305725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305725
Summary
Involved in negative regulation of neuron apoptotic process. Located in cytoplasm and extracellular region. Orthologous to human VSTM2L (V-set and transmembrane domain containing 2 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 120.1) See more
Orthologs
human mouse all
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Genomic context

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See Vstm2l in Genome Data Viewer
Location:
3q42
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (166991035..167020869)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (146571099..146600930)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (154395014..154424482)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene catenin, beta like 1 Neighboring gene mitochondrial pyruvate carrier 1-like, pseudogene 3 Neighboring gene uncharacterized LOC134486468 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene TELO2 interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin. Rossini L, et al. FASEB J, 2011 Jun. PMID 21393573
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
V-set and transmembrane domain-containing protein 2-like protein; similar to chromosome 20 open reading frame 102
Names
gene model 691,-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430743.1 → NP_001417672.1  similar to chromosome 20 open reading frame 102 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  2. NM_001430744.1 → NP_001417673.1  similar to chromosome 20 open reading frame 102 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    166991035..167020869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285125.1 → XP_063141195.1  V-set and transmembrane domain-containing protein 2-like protein isoform X2

  2. XM_342561.10 → XP_342562.5  V-set and transmembrane domain-containing protein 2-like protein isoform X1

    UniProtKB/TrEMBL
    D3ZDJ6
    Conserved Domains (2) summary
    pfam13927
    Location:43 → 144
    Ig_3; Immunoglobulin domain
    cd00096
    Location:50 → 52
    Ig; Ig strand A' [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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Chemical Information
Molecular Biology Databases
Research Materials