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Dhx35 DEAH-box helicase 35 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362260, updated on 28-Oct-2024

Summary

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Official Symbol
Dhx35provided by RGD
Official Full Name
DEAH-box helicase 35provided by RGD
Primary source
RGD:1311165
See related
EnsemblRapid:ENSRNOG00000015928 AllianceGenome:RGD:1311165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity and helicase activity. Predicted to act upstream of or within in utero embryonic development. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human DHX35 (DEAH-box helicase 35). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Heart (RPKM 61.8), Kidney (RPKM 55.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dhx35 in Genome Data Viewer
Location:
3q42
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (167869971..167927300)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (147450178..147507473)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (155297545..155354857)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 16B Neighboring gene 60S ribosomal protein L13-like Neighboring gene family with sequence similarity 83, member D Neighboring gene uncharacterized LOC134486305 Neighboring gene uncharacterized LOC108350510

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
  2. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DHX35
Names
DEAH (Asp-Glu-Ala-His) box polypeptide 35
NP_001102071.1
NP_001402786.1
XP_017447419.1
XP_038961441.1
XP_063140258.1
XP_063140259.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108601.2 → NP_001102071.1  probable ATP-dependent RNA helicase DHX35 isoform 2

    See identical proteins and their annotated locations for NP_001102071.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JWY0, A6JWY1, D4AEG5
    Related
    ENSRNOP00000021435.4, ENSRNOT00000021435.7
    Conserved Domains (5) summary
    smart00490
    Location:301 → 396
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:53 → 224
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:465 → 549
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:73 → 211
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:584 → 659
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  2. NM_001415857.1 → NP_001402786.1  probable ATP-dependent RNA helicase DHX35 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2JTM6
    Related
    ENSRNOP00000068770.1, ENSRNOT00000084866.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    167869971..167927300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105513.2 → XP_038961441.1  probable ATP-dependent RNA helicase DHX35 isoform X2

    Conserved Domains (1) summary
    COG1643
    Location:21 → 407
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

  2. XM_063284189.1 → XP_063140259.1  probable ATP-dependent RNA helicase DHX35 isoform X1

  3. XM_063284188.1 → XP_063140258.1  probable ATP-dependent RNA helicase DHX35 isoform X1

  4. XM_017591930.3 → XP_017447419.1  probable ATP-dependent RNA helicase DHX35 isoform X1

    UniProtKB/TrEMBL
    A6JWY1
    Conserved Domains (1) summary
    COG1643
    Location:1 → 527
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_352762.5 RNA Sequence

  2. XR_005501942.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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