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Ift52 intraflagellar transport 52 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362265, updated on 10-Oct-2024

Summary

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Official Symbol
Ift52provided by RGD
Official Full Name
intraflagellar transport 52provided by RGD
Primary source
RGD:1311004
See related
EnsemblRapid:ENSRNOG00000007692 AllianceGenome:RGD:1311004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311004
Summary
Predicted to be involved in cilium assembly and intraciliary anterograde transport. Predicted to act upstream of or within several processes, including embryonic morphogenesis; non-motile cilium assembly; and smoothened signaling pathway. Predicted to be located in several cellular components, including ciliary base; ciliary tip; and microtubule organizing center. Predicted to be part of intraciliary transport particle B. Predicted to be active in centriole and cilium. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human IFT52 (intraflagellar transport 52). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 158.3), Adrenal (RPKM 139.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ift52 in Genome Data Viewer
Location:
3q42
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (172091591..172116497)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (151672505..151696975)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (159388868..159413358)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene L3MBTL histone methyl-lysine binding protein 1 Neighboring gene serum/glucocorticoid regulated kinase 2 Neighboring gene uncharacterized LOC120101778 Neighboring gene 5S ribosomal RNA Neighboring gene MYB proto-oncogene like 2 Neighboring gene gametocyte specific factor 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome. Zhang W, et al. Hum Mol Genet, 2016 Sep 15. PMID 27466190, Free PMC Article
  2. The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly. Follit JA, et al. Mol Biol Cell, 2006 Sep. PMID 16775004, Free PMC Article
  3. Intraflagellar transport molecules in ciliary and nonciliary cells of the retina. Sedmak T, et al. J Cell Biol, 2010 Apr 5. PMID 20368623, Free PMC Article
  4. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Liu A, et al. Development, 2005 Jul. PMID 15930098
  5. SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium. Dharmat R, et al. J Cell Biol, 2018 Aug 6. PMID 29899041, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart looping ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary anterograde transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary tip ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite terminus ISO
Inferred from Sequence Orthology
more info
  
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor cell cilium ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor connecting cilium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
intraflagellar transport protein 52 homolog
Names
intraflagellar transport 52 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308389.1 → NP_001295318.1  intraflagellar transport protein 52 homolog

    See identical proteins and their annotated locations for NP_001295318.1

    Status: VALIDATED

    Source sequence(s)
    BC162007, JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JX12, D4A5T7
    Conserved Domains (1) summary
    cl23805
    Location:17 → 116
    ABC_transp_aux; ABC-type uncharacterized transport system

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    172091591..172116497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284213.1 → XP_063140283.1  intraflagellar transport protein 52 homolog isoform X2

    UniProtKB/TrEMBL
    A6JX12
    Related
    ENSRNOP00000059169.4, ENSRNOT00000066260.5

  2. XM_063284211.1 → XP_063140281.1  intraflagellar transport protein 52 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y075
    Related
    ENSRNOP00000076599.1, ENSRNOT00000113137.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177685.1: Suppressed sequence

    Description
    NM_001177685.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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