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Stx16 syntaxin 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362283, updated on 2-Nov-2024

Summary

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Official Symbol
Stx16provided by RGD
Official Full Name
syntaxin 16provided by RGD
Primary source
RGD:1309423
See related
EnsemblRapid:ENSRNOG00000005281 AllianceGenome:RGD:1309423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in several processes, including endosomal transport; vesicle docking; and vesicle fusion. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in pseudohypoparathyroidism type IB. Orthologous to human STX16 (syntaxin 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 94.4), Brain (RPKM 88.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stx16 in Genome Data Viewer
Location:
3q43
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (183271417..183300746)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (162853764..162882489)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (172154739..172183699)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486506 Neighboring gene uncharacterized LOC134486507 Neighboring gene aminopeptidase-like 1 Neighboring gene microRNA 296

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Syntaxin-16, a putative Golgi t-SNARE. Simonsen A, et al. Eur J Cell Biol, 1998 Mar. PMID 9587053
  2. The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners. Kreykenbohm V, et al. Eur J Cell Biol, 2002 May. PMID 12067063
  3. Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins. Amessou M, et al. J Cell Sci, 2007 Apr 15. PMID 17389686, Free PMC Article
  4. Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins. Tang BL, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464276
  5. Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16. Wang Y, et al. Mol Membr Biol, 2005 Jul-Aug. PMID 16154903

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
syntaxin-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401893.1 → NP_001388822.1  syntaxin-16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2K528
    Related
    ENSRNOP00000062099.3, ENSRNOT00000066279.3

  2. NM_001401894.1 → NP_001388823.1  syntaxin-16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    Related
    ENSRNOP00000073268.3, ENSRNOT00000088286.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    183271417..183300746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235694.5 → XP_006235756.1  syntaxin-16 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQ84, D3Z9R7
    Conserved Domains (2) summary
    cd15845
    Location:230 → 288
    SNARE_syntaxin16; SNARE motif of syntaxin 16
    cl00143
    Location:76 → 190
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

  2. XM_006235695.5 → XP_006235757.1  syntaxin-16 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZW54
    Conserved Domains (2) summary
    cd15845
    Location:217 → 275
    SNARE_syntaxin16; SNARE motif of syntaxin 16
    cl00143
    Location:63 → 177
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

RNA

  1. XR_005501944.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108610.1: Suppressed sequence

    Description
    NM_001108610.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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