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Cdk14 cyclin-dependent kinase 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362316, updated on 2-Nov-2024

Summary

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Official Symbol
Cdk14provided by RGD
Official Full Name
cyclin-dependent kinase 14provided by RGD
Primary source
RGD:1305544
See related
EnsemblRapid:ENSRNOG00000007151 AllianceGenome:RGD:1305544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pftk1
Summary
Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; regulation of canonical Wnt signaling pathway; and regulation of cell cycle phase transition. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytosol and nucleus. Orthologous to human CDK14 (cyclin dependent kinase 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 211.8), Lung (RPKM 200.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdk14 in Genome Data Viewer
Location:
4q13
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (29619237..30213651)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (28666416..29258865)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (25825567..26419443)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350663 Neighboring gene claudin 12 Neighboring gene PTTG1IP family member 2 Neighboring gene ribosomal protein S15a, pseudogene 6 Neighboring gene spermatogenesis associated glutamate (E)-rich protein 4C like 3 Neighboring gene uncharacterized LOC120102226 Neighboring gene frizzled class receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Serine/threonine-protein kinase PFTK1 modulates oligodendrocyte differentiation via PI3K/AKT pathway. Yang HJ, et al. J Mol Neurosci, 2015 Apr. PMID 25355490
  2. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Parmasad JA, et al. Cell Death Dis, 2024 Apr 4. PMID 38575601, Free PMC Article
  3. A novel cdc2-related protein kinase expressed in the nervous system. Lazzaro MA, et al. J Neurochem, 1997 Jul. PMID 9202329
  4. Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. Jiang M, et al. FEBS Lett, 2009 Jul 7. PMID 19524571
  5. Cell cycle control of wnt receptor activation. Davidson G, et al. Dev Cell, 2009 Dec. PMID 20059949

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
    Title: Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
  2. PFTK1 expression is markedly decreased during oligodendrocyte differentiation. PFTK1 overexpression suppresses oligodendrocyte differentiation in vitro.
    Title: Serine/threonine-protein kinase PFTK1 modulates oligodendrocyte differentiation via PI3K/AKT pathway.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 14
Names
PFTAIRE protein kinase 1
cell division protein kinase 14
NP_001382511.1
NP_001382512.1
NP_001382513.1
XP_038963685.1
XP_063142301.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395582.1 → NP_001382511.1  cyclin-dependent kinase 14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6A7V5, D3ZSZ0
    Related
    ENSRNOP00000100241.1, ENSRNOT00000170629.1

  2. NM_001395583.1 → NP_001382512.1  cyclin-dependent kinase 14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6A7V5, D3ZSZ0

  3. NM_001395584.1 → NP_001382513.1  cyclin-dependent kinase 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    D3ZSZ0
    Related
    ENSRNOP00000087492.2, ENSRNOT00000116950.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    29619237..30213651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107757.2 → XP_038963685.1  cyclin-dependent kinase 14 isoform X1

    UniProtKB/TrEMBL
    D3ZSZ0

  2. XM_063286231.1 → XP_063142301.1  cyclin-dependent kinase 14 isoform X1

    Related
    ENSRNOP00000082191.2, ENSRNOT00000094279.2

RNA

  1. XR_010065656.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108617.1: Suppressed sequence

    Description
    NM_001108617.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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