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Tcaf1 TRPM8 channel-associated factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362353, updated on 2-Nov-2024

Summary

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Official Symbol
Tcaf1provided by RGD
Official Full Name
TRPM8 channel-associated factor 1provided by RGD
Primary source
RGD:1565474
See related
EnsemblRapid:ENSRNOG00000017911 AllianceGenome:RGD:1565474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam115a; RGD1565474
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in negative regulation of cell migration; positive regulation of anion channel activity; and positive regulation of protein targeting to membrane. Predicted to be active in plasma membrane. Orthologous to human TCAF1 (TRPM8 channel associated factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 244.9), Brain (RPKM 171.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tcaf1 in Genome Data Viewer
Location:
4q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (72589710..72639304, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (71589674..71639274, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (72119349..72171733, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene TRPM8 channel associated factor 2C Neighboring gene TRPM8 channel-associated factor 2-like Neighboring gene olfactory receptor family 2 subfamily F member 5, pseudogene 1 Neighboring gene 40S ribosomal protein S23 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. Gkika D, et al. J Cell Biol, 2015 Jan 5. PMID 25559186, Free PMC Article
  2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of anion channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TRPM8 channel-associated factor 1
Names
family with sequence similarity 115, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399348.1 → NP_001386277.1  TRPM8 channel-associated factor 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IF86, D3Z8A4, D3ZFL9
    Related
    ENSRNOP00000024428.6, ENSRNOT00000024428.9
    Conserved Domains (2) summary
    pfam13402
    Location:633 → 890
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
    pfam17291
    Location:522 → 631
    M60-like_N; N-terminal domain of M60-like peptidases

  2. NM_001399349.1 → NP_001386278.1  TRPM8 channel-associated factor 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IF86, D3Z8A4, D3ZFL9
    Conserved Domains (2) summary
    pfam13402
    Location:633 → 890
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
    pfam17291
    Location:522 → 631
    M60-like_N; N-terminal domain of M60-like peptidases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    72589710..72639304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286251.1 → XP_063142321.1  TRPM8 channel-associated factor 1 isoform X1

    UniProtKB/TrEMBL
    A6IF86, D3Z8A4, D3ZFL9
Nucleotide Protein Strain
Heading Accession and Version

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