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Tril TLR4 interactor with leucine-rich repeats [ Rattus norvegicus (Norway rat) ]

Gene ID: 362364, updated on 2-Nov-2024

Summary

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Official Symbol
Trilprovided by RGD
Official Full Name
TLR4 interactor with leucine-rich repeatsprovided by RGD
Primary source
RGD:1310827
See related
EnsemblRapid:ENSRNOG00000026941 AllianceGenome:RGD:1310827
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310827
Summary
Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in regulation of cytokine production involved in immune response and toll-like receptor 4 signaling pathway. Predicted to be part of lipopolysaccharide receptor complex. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human TRIL (TLR4 interactor with leucine rich repeats). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See Tril in Genome Data Viewer
Location:
4q24
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (84252781..84257626, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (82922327..82927172, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (83967695..83972540, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 5 Neighboring gene uncharacterized LOC134486769 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene carboxypeptidase, vitellogenic-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain. Carpenter S, et al. J Immunol, 2009 Sep 15. PMID 19710467
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reports data for human and mouse TRIL
    Title: TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokine production involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of lipopolysaccharide receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of lipopolysaccharide receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TLR4 interactor with leucine rich repeats

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034010.2 → NP_001029182.1  TLR4 interactor with leucine rich repeats precursor

    See identical proteins and their annotated locations for NP_001029182.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q496Z2
    UniProtKB/TrEMBL
    A6K0U0
    Related
    ENSRNOP00000037327.1, ENSRNOT00000036951.4
    Conserved Domains (6) summary
    smart00060
    Location:589 → 661
    FN3; Fibronectin type 3 domain
    cd00116
    Location:22 → 313
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:327 → 340
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:85 → 108
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:229 → 289
    LRR_8; Leucine rich repeat
    cl15307
    Location:359 → 406
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    84252781..84257626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q496Z2.1 GenPept UniProtKB/Swiss-Prot:Q496Z2

Gene LinkOut

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