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Vopp1 VOPP1 WW domain binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 362374, updated on 2-Nov-2024

Summary

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Official Symbol
Vopp1provided by RGD
Official Full Name
VOPP1 WW domain binding proteinprovided by RGD
Primary source
RGD:1306494
See related
EnsemblRapid:ENSRNOG00000006646 AllianceGenome:RGD:1306494
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ecop; RGD1306494
Summary
Predicted to enable enzyme binding activity. Predicted to be located in cytoplasmic vesicle membrane; late endosome; and lysosome. Predicted to be active in organelle membrane. Orthologous to human VOPP1 (VOPP1 WW domain binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 333.5), Brain (RPKM 209.9) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Vopp1 in Genome Data Viewer
Location:
4q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (88692784..88762903)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (87363678..87432747)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (88441067..88515141)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor pseudogene 111 Neighboring gene vomeronasal 1 receptor 88 Neighboring gene LanC like glutathione S-transferase 2 Neighboring gene PIGY upstream open reading frame

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Intracellular localization of GASP/ECOP/VOPP1. Baras A, et al. J Mol Histol, 2010 Apr. PMID 20571887
  2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in organelle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WW domain binding protein VOPP1
Names
EGFR-coamplified and overexpressed protein
VOPP1, WBP1/VOPP1 family member
vesicular, overexpressed in cancer, prosurvival protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108630.1 → NP_001102100.1  WW domain binding protein VOPP1 precursor

    See identical proteins and their annotated locations for NP_001102100.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474011
    UniProtKB/Swiss-Prot
    B5DEK8
    UniProtKB/TrEMBL
    A0A8I6AIE2
    Related
    ENSRNOP00000008885.4, ENSRNOT00000008885.7
    Conserved Domains (1) summary
    cl25887
    Location:102 → 155
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    88692784..88762903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286275.1 → XP_063142345.1  WW domain binding protein VOPP1 isoform X3

    UniProtKB/TrEMBL
    A6K127

  2. XM_063286274.1 → XP_063142344.1  WW domain binding protein VOPP1 isoform X2

    Related
    ENSRNOP00000080713.1, ENSRNOT00000095430.2

  3. XM_063286277.1 → XP_063142347.1  WW domain binding protein VOPP1 isoform X3

    UniProtKB/TrEMBL
    A6K127

  4. XM_006236578.5 → XP_006236640.1  WW domain binding protein VOPP1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIE2
    Related
    ENSRNOP00000104621.1, ENSRNOT00000122148.1
    Conserved Domains (1) summary
    cl25887
    Location:85 → 138
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  5. XM_063286276.1 → XP_063142346.1  WW domain binding protein VOPP1 isoform X3

    UniProtKB/TrEMBL
    A6K127
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5DEK8.1 GenPept UniProtKB/Swiss-Prot:B5DEK8

Gene LinkOut

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