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Plxna1 plexin A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362398, updated on 28-Oct-2024

Summary

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Official Symbol
Plxna1provided by RGD
Official Full Name
plexin A1provided by RGD
Primary source
RGD:1560871
See related
EnsemblRapid:ENSRNOG00000017003 AllianceGenome:RGD:1560871
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560871
Summary
Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including nervous system development; positive regulation of axonogenesis; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection extension; and regulation of smooth muscle cell migration. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be part of semaphorin receptor complex. Predicted to be active in glutamatergic synapse and plasma membrane. Orthologous to human PLXNA1 (plexin A1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Lung (RPKM 197.4), Adrenal (RPKM 91.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plxna1 in Genome Data Viewer
Location:
4q34
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (123295165..123340132, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (121737934..121782901, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (121217658..121262697, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102339 Neighboring gene uncharacterized LOC120102340 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 6 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential expression of plexin-A subfamily members in the mouse nervous system. Murakami Y, et al. Dev Dyn, 2001 Mar. PMID 11241833
  2. Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. Toyofuku T, et al. Genes Dev, 2004 Feb 15. PMID 14977921, Free PMC Article
  3. Semaphorin signaling facilitates cleft formation in the developing salivary gland. Chung L, et al. Development, 2007 Aug. PMID 17626059
  4. Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function. Matsuoka RL, et al. Neuron, 2011 Aug 11. PMID 21835343, Free PMC Article
  5. PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Gitler AD, et al. Dev Cell, 2004 Jul. PMID 15239958

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching ISO
Inferred from Sequence Orthology
more info
  
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron projection extension ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron projection guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in olfactory nerve formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within semaphorin-plexin signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of semaphorin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
plexin-A1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    123295165..123340132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002729398.6 → XP_002729444.2  plexin-A1

    See identical proteins and their annotated locations for XP_002729444.2

    UniProtKB/TrEMBL
    A0A8I6AGW9, A6IB60, D3Z981
    Related
    ENSRNOP00000099946.1, ENSRNOT00000137358.1
    Conserved Domains (7) summary
    cd11271
    Location:54 → 529
    Sema_plexin_A1; The Sema domain, a protein interacting module, of Plexin A1
    cd01179
    Location:977 → 1062
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:880 → 976
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:1064 → 1164
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:530 → 572
    PSI; Plexin repeat
    pfam01833
    Location:1166 → 1250
    TIG; IPT/TIG domain
    pfam08337
    Location:1334 → 1882
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
Nucleotide Protein Strain
Heading Accession and Version

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