U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rad18 RAD18 E3 ubiquitin protein ligase [ Rattus norvegicus (Norway rat) ]

Gene ID: 362412, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Rad18provided by RGD
Official Full Name
RAD18 E3 ubiquitin protein ligaseprovided by RGD
Primary source
RGD:1306993
See related
EnsemblRapid:ENSRNOG00000005907 AllianceGenome:RGD:1306993
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including Y-form DNA binding activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of chromosome segregation; postreplication repair; and protein monoubiquitination. Predicted to act upstream of or within several processes, including negative regulation of DNA recombination; protein autoubiquitination; and response to UV. Predicted to be located in centrosome; chromosome; and nucleus. Predicted to be part of Rad6-Rad18 complex. Predicted to be active in nucleus. Orthologous to human RAD18 (RAD18 E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 140.0), Thymus (RPKM 68.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rad18 in Genome Data Viewer
Location:
4q42
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (147291463..147376904, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (145735654..145821102, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (144537329..144620606, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene caveolin 3 Neighboring gene oxytocin receptor Neighboring gene uncharacterized LOC102548080 Neighboring gene SLIT-ROBO Rho GTPase activating protein 3 Neighboring gene small nucleolar RNA U3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A natural antisense transcript against Rad18, specifically expressed in neurons and upregulated during beta-amyloid-induced apoptosis. Parenti R, et al. Eur J Neurosci, 2007 Nov. PMID 17970741
  2. Rad18 is required for long-term maintenance of spermatogenesis in mouse testes. Sun J, et al. Mech Dev, 2009 Mar-Apr. PMID 19068231
  3. Characterization of mRAD18Sc, a mouse homolog of the yeast postreplication repair gene RAD18. van der Laan R, et al. Genomics, 2000 Oct 1. PMID 11013078
  4. Formation of D-serine from L-phosphoserine in brain synaptosomes. Wood PL, et al. J Neurochem, 1996 Oct. PMID 8858931
  5. Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells. Tateishi S, et al. Mol Cell Biol, 2003 Jan. PMID 12509447, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These experiments suggest the existence of a natural antisense transcript (NAT) that exerts a post-transcriptional control over Rad18.
    Title: A natural antisense transcript against Rad18, specifically expressed in neurons and upregulated during beta-amyloid-induced apoptosis.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC156682

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Y-form DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within negative regulation of DNA recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to UV ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Rad6-Rad18 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in XY body ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inclusion body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in replication fork ISO
Inferred from Sequence Orthology
more info
  
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase RAD18
Names
RAD18 homolog
NP_001071141.1
XP_006237098.1
XP_006237099.1
XP_063142360.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077673.1 → NP_001071141.1  E3 ubiquitin-protein ligase RAD18

    See identical proteins and their annotated locations for NP_001071141.1

    Status: PROVISIONAL

    Source sequence(s)
    BC127510
    UniProtKB/TrEMBL
    A0A8I5YBD2, A0JPN0
    Related
    ENSRNOP00000063400.1, ENSRNOT00000066468.4
    Conserved Domains (4) summary
    smart00734
    Location:201 → 224
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd00162
    Location:25 → 63
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    TIGR00599
    Location:13 → 363
    rad18; DNA repair protein rad18
    pfam02037
    Location:248 → 282
    SAP; SAP domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    147291463..147376904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286290.1 → XP_063142360.1  E3 ubiquitin-protein ligase RAD18 isoform X3

    Related
    ENSRNOP00000076533.2, ENSRNOT00000099439.2

  2. XM_006237036.4 → XP_006237098.1  E3 ubiquitin-protein ligase RAD18 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBD2
    Conserved Domains (4) summary
    smart00734
    Location:201 → 224
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd00162
    Location:25 → 63
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    TIGR00599
    Location:13 → 363
    rad18; DNA repair protein rad18
    pfam02037
    Location:248 → 282
    SAP; SAP domain

  3. XM_006237037.4 → XP_006237099.1  E3 ubiquitin-protein ligase RAD18 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GKR5, A6IBN3
    Related
    ENSRNOP00000094440.1, ENSRNOT00000115978.2
    Conserved Domains (4) summary
    smart00734
    Location:201 → 224
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd00162
    Location:25 → 63
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    TIGR00599
    Location:13 → 363
    rad18; DNA repair protein rad18
    pfam02037
    Location:248 → 282
    SAP; SAP domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous