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Ncapd2 non-SMC condensin I complex, subunit D2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362438, updated on 2-Nov-2024

Summary

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Official Symbol
Ncapd2provided by RGD
Official Full Name
non-SMC condensin I complex, subunit D2provided by RGD
Primary source
RGD:1562596
See related
EnsemblRapid:ENSRNOG00000055300 AllianceGenome:RGD:1562596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562596
Summary
Predicted to enable histone binding activity. Predicted to be involved in chromosome condensation; positive regulation of chromosome condensation; and regulation of chromosome segregation. Predicted to be located in cytosol and nucleus. Predicted to be part of condensin complex. Predicted to be active in condensed chromosome, centromeric region. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 230.7), Spleen (RPKM 144.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ncapd2 in Genome Data Viewer
Location:
4q42
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159655051..159677938, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157968814..157992314, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157682855..157705903, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene intermediate filament family orphan 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase Neighboring gene small Cajal body-specific RNA 10 Neighboring gene mitochondrial ribosomal protein L51 Neighboring gene vesicle-associated membrane protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7. Ball AR Jr, et al. Mol Cell Biol, 2002 Aug. PMID 12138188, Free PMC Article
  2. Differential regulation of maternal and paternal chromosome condensation in mitotic zygotes. Bomar J, et al. J Cell Sci, 2002 Jul 15. PMID 12082153
  3. Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis. Martin CA, et al. Genes Dev, 2016 Oct 1. PMID 27737959, Free PMC Article
  4. Chromosome condensation by a human condensin complex in Xenopus egg extracts. Kimura K, et al. J Biol Chem, 2001 Feb 23. PMID 11136719
  5. Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes. Lee J, et al. Mol Biol Cell, 2011 Sep. PMID 21795393, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in condensed chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in pronucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
condensin complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399442.2 → NP_001386371.1  condensin complex subunit 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6ILS7
    Related
    ENSRNOP00000069882.3, ENSRNOT00000083016.3
    Conserved Domains (2) summary
    COG5098
    Location:185 → 1234
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    pfam12922
    Location:75 → 240
    Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    159655051..159677938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_575668.9 → XP_575668.6  condensin complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWH3
    Conserved Domains (2) summary
    COG5098
    Location:185 → 1234
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    pfam12922
    Location:75 → 240
    Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

  2. XM_063286359.1 → XP_063142429.1  condensin complex subunit 1 isoform X3

  3. XM_039108815.2 → XP_038964743.1  condensin complex subunit 1 isoform X2

    Related
    ENSRNOP00000102742.1, ENSRNOT00000161204.1
    Conserved Domains (2) summary
    COG5098
    Location:147 → 1196
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    pfam12922
    Location:37 → 202
    Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

  4. XM_039108816.2 → XP_038964744.1  condensin complex subunit 1 isoform X5

    Conserved Domains (2) summary
    COG5098
    Location:67 → 1116
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    pfam12922
    Location:1 → 122
    Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

  5. XM_039108817.2 → XP_038964745.1  condensin complex subunit 1 isoform X6

    Conserved Domains (1) summary
    COG5098
    Location:1 → 626
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]

  6. XM_063286360.1 → XP_063142430.1  condensin complex subunit 1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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