Arhgdib Rho GDP dissociation inhibitor beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgdibprovided by RGD
Official Full Name: Rho GDP dissociation inhibitor betaprovided by RGD
Primary source: RGD:1305383
See related: EnsemblRapid:ENSRNOG00000005809 AllianceGenome:RGD:1305383
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activity; Rho GDP-dissociation inhibitor activity; and small GTPase binding activity. Involved in cellular response to redox state. Predicted to be active in cytosol and membrane. Orthologous to human ARHGDIB (Rho GDP dissociation inhibitor beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 1212.6), Spleen (RPKM 1038.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q43

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (171554139..171573057, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (169822951..169841884, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (170913920..170932789, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that RhoGDIbeta physically interacts with ZAK and is phosphorylated by ZAK in vitro, and this phosphorylation negatively regulates RhoGDIbeta functions.
Title: RhoGDIbeta-induced hypertrophic growth in H9c2 cells is negatively regulated by ZAK.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130748 (e-PCR)
- UniSTS:214032

D4Wox38 (e-PCR)
- UniSTS:239488

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables Rho GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rho GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to redox state	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of trophoblast cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho GDP-dissociation inhibitor 2

Names: Rho, GDP dissociation inhibitor (GDI) beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.