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Bmal2 basic helix-loop-helix ARNT like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362464, updated on 2-Nov-2024

Summary

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Official Symbol
Bmal2provided by RGD
Official Full Name
basic helix-loop-helix ARNT like 2provided by RGD
Primary source
RGD:620230
See related
EnsemblRapid:ENSRNOG00000001830 AllianceGenome:RGD:620230
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arnt4; Arntl2
Summary
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (Per, Arnt, Sim) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian Clock protein, the structurally related Mop4, and hypoxia-inducible factors, such as Hif1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. [provided by RefSeq, Feb 2014]
Expression
Biased expression in Adrenal (RPKM 8.6), Liver (RPKM 6.8) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bmal2 in Genome Data Viewer
Location:
4q44
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (181429097..181478384)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (179699432..179747710)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (181103774..181158415)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 21 Neighboring gene serine/threonine kinase 38 like Neighboring gene single-pass membrane protein with coiled-coil domains 2 Neighboring gene PPFIA binding protein 1 Neighboring gene similar to human chromosome 12 open reading frame 71

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Increased sensitivity of the circadian system to temporal changes in the feeding regime of spontaneously hypertensive rats - a potential role for Bmal2 in the liver. Polidarová L, et al. PLoS One, 2013. PMID 24086613, Free PMC Article
  2. Early chronotype and tissue-specific alterations of circadian clock function in spontaneously hypertensive rats. Sládek M, et al. PLoS One, 2012. PMID 23056539, Free PMC Article
  3. Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization. Schoenhard JA, et al. Am J Physiol Cell Physiol, 2002 Jul. PMID 12055078
  4. Cloning of mouse BMAL2 and its daily expression profile in the suprachiasmatic nucleus: a remarkable acceleration of Bmal2 sequence divergence after Bmal gene duplication. Okano T, et al. Neurosci Lett, 2001 Mar 9. PMID 11207387
  5. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Woon PY, et al. Proc Natl Acad Sci U S A, 2007 Sep 4. PMID 17728404, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Bmal2 gene in the higher sensitivity of the hepatic clock.
    Title: Increased sensitivity of the circadian system to temporal changes in the feeding regime of spontaneously hypertensive rats - a potential role for Bmal2 in the liver.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables E-box binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CLOCK-BMAL transcription complex ISO
Inferred from Sequence Orthology
more info
  
part_of aryl hydrocarbon receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
basic helix-loop-helix ARNT-like protein 2
Names
aryl hydrocarbon receptor nuclear translocator-like 2
aryl hydrocarbon receptor nuclear translocator-like protein 2
aryl hydrocarbon receptor nuclear translocator-like protein 2-like
transcription factor BMAL2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133391.2 → NP_596882.2  basic helix-loop-helix ARNT-like protein 2

    Status: PROVISIONAL

    Source sequence(s)
    AY014838, JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2JYF4
    Related
    ENSRNOP00000070632.2, ENSRNOT00000077619.3
    Conserved Domains (2) summary
    cd00083
    Location:50 → 106
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cl25986
    Location:280 → 382
    PAS_3; PAS fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    181429097..181478384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107944.2 → XP_038963872.1  basic helix-loop-helix ARNT-like protein 2 isoform X1

    UniProtKB/TrEMBL
    H9CTG8
    Related
    ENSRNOP00000071979.3, ENSRNOT00000084207.3
    Conserved Domains (3) summary
    cd00130
    Location:171 → 268
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:357 → 464
    PAS_11; PAS domain
    cl00081
    Location:87 → 146
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  2. XM_039107946.2 → XP_038963874.1  basic helix-loop-helix ARNT-like protein 2 isoform X3

    UniProtKB/TrEMBL
    Q923L9
    Related
    ENSRNOP00000052338.6, ENSRNOT00000055473.6
    Conserved Domains (3) summary
    cd00130
    Location:137 → 234
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:323 → 430
    PAS_11; PAS domain
    cl00081
    Location:54 → 112
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  3. XM_039107945.2 → XP_038963873.1  basic helix-loop-helix ARNT-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K1T7, H9CTG8
    Conserved Domains (3) summary
    cd00130
    Location:171 → 260
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:349 → 456
    PAS_11; PAS domain
    cl00081
    Location:87 → 146
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  4. XM_039107947.2 → XP_038963875.1  basic helix-loop-helix ARNT-like protein 2 isoform X4

    UniProtKB/TrEMBL
    Q923L9
    Conserved Domains (3) summary
    cd00130
    Location:137 → 226
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:315 → 422
    PAS_11; PAS domain
    cl00081
    Location:54 → 112
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  5. XM_039107948.2 → XP_038963876.1  basic helix-loop-helix ARNT-like protein 2 isoform X5

    UniProtKB/TrEMBL
    A6IN33
    Conserved Domains (1) summary
    pfam14598
    Location:156 → 263
    PAS_11; PAS domain

  6. XM_039107951.2 → XP_038963879.1  basic helix-loop-helix ARNT-like protein 2 isoform X7

    UniProtKB/TrEMBL
    A6IN33
    Conserved Domains (1) summary
    pfam14598
    Location:86 → 193
    PAS_11; PAS domain

  7. XM_039107949.2 → XP_038963877.1  basic helix-loop-helix ARNT-like protein 2 isoform X5

    UniProtKB/TrEMBL
    A6IN33
    Conserved Domains (1) summary
    pfam14598
    Location:156 → 263
    PAS_11; PAS domain

  8. XM_039107950.2 → XP_038963878.1  basic helix-loop-helix ARNT-like protein 2 isoform X6

    UniProtKB/TrEMBL
    A6IN33
    Conserved Domains (1) summary
    pfam14598
    Location:148 → 255
    PAS_11; PAS domain
Nucleotide Protein Strain
Heading Accession and Version

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