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Tmtc1 transmembrane O-mannosyltransferase targeting cadherins 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362465, updated on 17-Aug-2024

Summary

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Official Symbol
Tmtc1provided by RGD
Official Full Name
transmembrane O-mannosyltransferase targeting cadherins 1provided by RGD
Primary source
RGD:1564868
See related
EnsemblRapid:ENSRNOG00000001854 AllianceGenome:RGD:1564868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564868
Summary
Predicted to enable mannosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Orthologous to human TMTC1 (transmembrane O-mannosyltransferase targeting cadherins 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 100.8), Lung (RPKM 89.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q44
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (182874350..183089408, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (181142937..181357979, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (182620132..182845620, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene fatty acyl CoA reductase 2 Neighboring gene ERGIC and golgi 2 Neighboring gene ribosomal protein S4, X-linked, pseudogene 13 Neighboring gene thymosin beta-10-like Neighboring gene uncharacterized LOC120102437

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. Larsen ISB, et al. Proc Natl Acad Sci U S A, 2017 Oct 17. PMID 28973932, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein O-mannosyl-transferase TMTC1; transmembrane O-mannosyltransferase targeting cadherins 1
Names
transmembrane and TPR repeat-containing protein 1
transmembrane and tetratricopeptide repeat containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431791.1 → NP_001418720.1  transmembrane O-mannosyltransferase targeting cadherins 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  2. NM_001431792.1 → NP_001418721.1  transmembrane O-mannosyltransferase targeting cadherins 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    182874350..183089408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108900.2 → XP_038964828.1  protein O-mannosyl-transferase TMTC1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZ24
    Related
    ENSRNOP00000084348.1, ENSRNOT00000114970.2
    Conserved Domains (3) summary
    TIGR02917
    Location:500 → 904
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:604 → 632
    TPR; TPR repeat [structural motif]
    pfam08409
    Location:352 → 425
    DUF1736; Domain of unknown function (DUF1736)

  2. XM_039108899.2 → XP_038964827.1  protein O-mannosyl-transferase TMTC1 isoform X1

    UniProtKB/TrEMBL
    D4A2M3
    Related
    ENSRNOP00000100951.1, ENSRNOT00000144032.1
    Conserved Domains (3) summary
    TIGR02917
    Location:529 → 942
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:543 → 571
    TPR; TPR repeat [structural motif]
    pfam08409
    Location:352 → 425
    DUF1736; Domain of unknown function (DUF1736)

  3. XM_063286870.1 → XP_063142940.1  protein O-mannosyl-transferase TMTC1 isoform X4

    Related
    ENSRNOP00000109563.1, ENSRNOT00000160308.1

  4. XM_063286869.1 → XP_063142939.1  protein O-mannosyl-transferase TMTC1 isoform X3

    Related
    ENSRNOP00000103955.1, ENSRNOT00000158656.1

  5. XM_039108901.2 → XP_038964829.1  protein O-mannosyl-transferase TMTC1 isoform X5

    Conserved Domains (3) summary
    TIGR02917
    Location:505 → 649
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:543 → 571
    TPR; TPR repeat [structural motif]
    pfam08409
    Location:352 → 425
    DUF1736; Domain of unknown function (DUF1736)

  6. XM_039108902.2 → XP_038964830.1  protein O-mannosyl-transferase TMTC1 isoform X6

    Conserved Domains (1) summary
    pfam08409
    Location:352 → 425
    DUF1736; Domain of unknown function (DUF1736)
Nucleotide Protein Strain
Heading Accession and Version

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