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Ptpn3 protein tyrosine phosphatase, non-receptor type 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362524, updated on 18-Sep-2024

Summary

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Official Symbol
Ptpn3provided by RGD
Official Full Name
protein tyrosine phosphatase, non-receptor type 3provided by RGD
Primary source
RGD:1311363
See related
EnsemblRapid:ENSRNOG00000011425 AllianceGenome:RGD:1311363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATPase binding activity; phosphotyrosine residue binding activity; and sodium channel regulator activity. Involved in liver regeneration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Orthologous to human PTPN3 (protein tyrosine phosphatase non-receptor type 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 122.7), Muscle (RPKM 120.1) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptpn3 in Genome Data Viewer
Location:
5q24
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (76703687..76822584, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (71908520..72027323, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (74248996..74368167, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ferric-chelate reductase 1-like Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene uncharacterized LOC108350978 Neighboring gene uncharacterized LOC134486937 Neighboring gene uncharacterized LOC102556038 Neighboring gene uncharacterized LOC100910620

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1. Jespersen T, et al. Biochem Biophys Res Commun, 2006 Oct 6. PMID 16930557
  2. Gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells. Kitamura T, et al. Jpn J Cancer Res, 1995 Sep. PMID 7591957, Free PMC Article
  3. Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. Zheng Y, et al. J Biol Chem, 2002 Nov 8. PMID 12207026
  4. Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1. Zhang SH, et al. J Biol Chem, 1999 Jun 18. PMID 10364224
  5. Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Gjörloff-Wingren A, et al. Eur J Immunol, 2000 Aug. PMID 10940933

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane depolarization during action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 3
NP_001094224.1
XP_001059757.1
XP_008761962.1
XP_017449225.1
XP_038966966.1
XP_063144002.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100754.1 → NP_001094224.1  tyrosine-protein phosphatase non-receptor type 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5YBL2
    Related
    ENSRNOP00000077016.2, ENSRNOT00000104839.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    76703687..76822584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593736.3 → XP_017449225.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5YBL2
    Conserved Domains (4) summary
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00992
    Location:508 → 595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14600
    Location:631 → 904
    PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

  2. XM_001059757.6 → XP_001059757.1  tyrosine-protein phosphatase non-receptor type 3 isoform X1

    See identical proteins and their annotated locations for XP_001059757.1

    UniProtKB/TrEMBL
    A0A096MJA1, A6KDS9, F1LQQ5
    Related
    ENSRNOP00000068252.3, ENSRNOT00000076705.3
    Conserved Domains (7) summary
    smart00194
    Location:754 → 1005
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:135 → 327
    B41; Band 4.1 homologues
    cd00047
    Location:777 → 1004
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:613 → 700
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:321 → 414
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam00373
    Location:220 → 327
    FERM_M; FERM central domain
    pfam09379
    Location:138 → 201
    FERM_N; FERM N-terminal domain

  3. XM_063287932.1 → XP_063144002.1  tyrosine-protein phosphatase non-receptor type 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBL2
    Related
    ENSRNOP00000101241.1, ENSRNOT00000158623.1

  4. XM_039111038.2 → XP_038966966.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5YBL2
    Conserved Domains (4) summary
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00992
    Location:508 → 595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14600
    Location:631 → 904
    PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

  5. XM_008763740.4 → XP_008761962.1  tyrosine-protein phosphatase non-receptor type 3 isoform X4

    See identical proteins and their annotated locations for XP_008761962.1

    Conserved Domains (4) summary
    smart00194
    Location:417 → 668
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:440 → 667
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:276 → 363
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17171
    Location:1 → 77
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version

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