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Akna AT-hook transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 362530, updated on 2-Nov-2024

Summary

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Official Symbol
Aknaprovided by RGD
Official Full Name
AT-hook transcription factorprovided by RGD
Primary source
RGD:1308202
See related
EnsemblRapid:ENSRNOG00000008005 AllianceGenome:RGD:1308202
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including neuroblast delamination; neuroblast division in subventricular zone; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; microtubule cytoskeleton; and nuclear lumen. Predicted to be active in centrosome. Orthologous to human AKNA (AT-hook transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 144.1), Spleen (RPKM 90.1) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Akna in Genome Data Viewer
Location:
5q24
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (81792928..81839936, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (76777415..76824380, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (79184087..79232370, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene collagen type XXVII alpha 1 chain Neighboring gene microRNA 455 Neighboring gene orosomucoid 1 Neighboring gene uncharacterized LOC102547858 Neighboring gene whirlin Neighboring gene H/ACA ribonucleoprotein complex subunit 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PKA/CREB and NF-κB pathway regulates AKNA transcription: A novel insight into T-2 toxin-induced inflammation and GH deficiency in GH3 cells. Liu X, et al. Toxicology, 2017 Dec 1. PMID 29079362
  2. Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Ma W, et al. Cell Res, 2011 Nov. PMID 21606955, Free PMC Article
  3. Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA. Siddiqa A, et al. Nature, 2001 Mar 15. PMID 11268217
  4. The centrosome protein AKNA regulates neurogenesis via microtubule organization. Camargo Ortega G, et al. Nature, 2019 Mar. PMID 30787442
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in delamination ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial to mesenchymal transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in neuroblast delamination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuroblast delamination ISO
Inferred from Sequence Orthology
more info
  
involved_in neuroblast division in subventricular zone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuroblast division in subventricular zone ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microtubule organization protein AKNA
Names
AT-hook-containing transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108668.1 → NP_001102138.1  microtubule organization protein AKNA

    See identical proteins and their annotated locations for NP_001102138.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473978
    UniProtKB/TrEMBL
    A0A8I5ZL68, A6J7Y1, D3ZLV5
    Related
    ENSRNOP00000010515.5, ENSRNOT00000010516.7
    Conserved Domains (1) summary
    pfam12443
    Location:583 → 674
    AKNA; AT-hook-containing transcription factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    81792928..81839936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238257.5 → XP_006238319.1  microtubule organization protein AKNA isoform X1

    See identical proteins and their annotated locations for XP_006238319.1

    UniProtKB/TrEMBL
    A0A8I5ZL68, A6J7Y1, D3ZLV5
    Conserved Domains (1) summary
    pfam12443
    Location:583 → 674
    AKNA; AT-hook-containing transcription factor

  2. XM_063287937.1 → XP_063144007.1  microtubule organization protein AKNA isoform X1

    UniProtKB/TrEMBL
    A6J7Y1, D3ZLV5

  3. XM_063287938.1 → XP_063144008.1  microtubule organization protein AKNA isoform X2

  4. XM_039110253.2 → XP_038966181.1  microtubule organization protein AKNA isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZL68, A6J7Y1, D3ZLV5
    Conserved Domains (1) summary
    pfam12443
    Location:583 → 674
    AKNA; AT-hook-containing transcription factor

  5. XM_039110254.2 → XP_038966182.1  microtubule organization protein AKNA isoform X3

    Conserved Domains (1) summary
    pfam12443
    Location:583 → 674
    AKNA; AT-hook-containing transcription factor

RNA

  1. XR_005504479.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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