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Hacd4 3-hydroxyacyl-CoA dehydratase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362540, updated on 2-Nov-2024

Summary

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Official Symbol
Hacd4provided by RGD
Official Full Name
3-hydroxyacyl-CoA dehydratase 4provided by RGD
Primary source
RGD:1310339
See related
EnsemblRapid:ENSRNOG00000005772 AllianceGenome:RGD:1310339
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ptplad2; RGD1310339
Summary
Predicted to enable enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human HACD4 (3-hydroxyacyl-CoA dehydratase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 82.2), Spleen (RPKM 49.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hacd4 in Genome Data Viewer
Location:
5q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (107935514..107961271, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (102887597..102915376, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (106728401..106758068, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene MLLT3, super elongation complex subunit Neighboring gene small nucleolar RNA SNORA17 Neighboring gene focadhesin Neighboring gene interferon beta 1 Neighboring gene interferon, alpha 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis. Ikeda M, et al. FEBS Lett, 2008 Jul 9. PMID 18554506
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fatty acid elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4
Names
protein tyrosine phosphatase-like A domain containing 2
protein tyrosine phosphatase-like protein PTPLAD2
NP_001102139.1
XP_006238438.1
XP_038966193.1
XP_063144013.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108669.1 → NP_001102139.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4

    See identical proteins and their annotated locations for NP_001102139.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474094
    UniProtKB/TrEMBL
    A6KRA5
    Related
    ENSRNOP00000095794.2, ENSRNOT00000101049.2
    Conserved Domains (1) summary
    pfam04387
    Location:65 → 222
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    107935514..107961271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238376.5 → XP_006238438.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AU59
    Related
    ENSRNOP00000099570.1, ENSRNOT00000139632.1
    Conserved Domains (1) summary
    pfam04387
    Location:65 → 209
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

  2. XM_039110265.2 → XP_038966193.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform X2

    UniProtKB/TrEMBL
    D3Z8V6
    Related
    ENSRNOP00000034988.4, ENSRNOT00000033651.7
    Conserved Domains (1) summary
    pfam04387
    Location:65 → 206
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

  3. XM_063287943.1 → XP_063144013.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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