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Trit1 tRNA isopentenyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362586, updated on 2-Nov-2024

Summary

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Official Symbol
Trit1provided by RGD
Official Full Name
tRNA isopentenyltransferase 1provided by RGD
Primary source
RGD:1304781
See related
EnsemblRapid:ENSRNOG00000014274 AllianceGenome:RGD:1304781
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable tRNA dimethylallyltransferase activity. Predicted to be involved in mitochondrial tRNA modification. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Orthologous to human TRIT1 (tRNA isopentenyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 104.0), Adrenal (RPKM 97.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trit1 in Genome Data Viewer
Location:
5q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (140578459..140623881)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135293472..135341522)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (140711943..140756893)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909490 Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene MYCL proto-oncogene, bHLH transcription factor Neighboring gene bone morphogenetic protein 8b Neighboring gene 3-oxoacid CoA transferase 2B Neighboring gene peptidylprolyl isomerase E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Defective i6A37 modification of mitochondrial and cytosolic tRNAs results from pathogenic mutations in TRIT1 and its substrate tRNA. Yarham JW, et al. PLoS Genet, 2014 Jun. PMID 24901367, Free PMC Article
  2. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dimethylallyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA dimethylallyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA dimethylallyltransferase
Names
tRNA dimethylallyltransferase, mitochondrial
NP_001102146.1
XP_006238866.1
XP_038966235.1
XP_038966237.1
XP_063144055.1
XP_063144056.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108676.1 → NP_001102146.1  tRNA dimethylallyltransferase

    See identical proteins and their annotated locations for NP_001102146.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    A6IS14, D4A175
    Related
    ENSRNOP00000019587.4, ENSRNOT00000019587.6
    Conserved Domains (3) summary
    PLN02748
    Location:25 → 440
    PLN02748; tRNA dimethylallyltransferase
    PRK00091
    Location:24 → 345
    miaA; tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed
    pfam12171
    Location:407 → 431
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    140578459..140623881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110307.2 → XP_038966235.1  tRNA dimethylallyltransferase isoform X1

    Conserved Domains (3) summary
    pfam01715
    Location:80 → 354
    IPPT; IPP transferase
    pfam12171
    Location:416 → 440
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl17190
    Location:17 → 55
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. XM_006238804.5 → XP_006238866.1  tRNA dimethylallyltransferase isoform X2

    Conserved Domains (2) summary
    PRK00091
    Location:24 → 333
    miaA; tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed
    pfam12171
    Location:395 → 419
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  3. XM_063287986.1 → XP_063144056.1  tRNA dimethylallyltransferase isoform X3

  4. XM_063287985.1 → XP_063144055.1  tRNA dimethylallyltransferase isoform X1

  5. XM_039110309.2 → XP_038966237.1  tRNA dimethylallyltransferase isoform X4

    Conserved Domains (2) summary
    pfam01715
    Location:7 → 106
    IPPT; IPP transferase
    pfam12171
    Location:168 → 192
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

RNA

  1. XR_005504486.2 RNA Sequence

  2. XR_010066422.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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