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Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362588, updated on 2-Nov-2024

Summary

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Official Symbol
Ndufs5provided by RGD
Official Full Name
NADH:ubiquinone oxidoreductase subunit S5provided by RGD
Primary source
RGD:1311081
See related
EnsemblRapid:ENSRNOG00000026646 AllianceGenome:RGD:1311081
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ndufs5b
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Orthologous to human NDUFS5 (NADH:ubiquinone oxidoreductase subunit S5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 2134.6), Muscle (RPKM 1143.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ndufs5 in Genome Data Viewer
Location:
5q36
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (141258828..141264552, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135974029..135979705, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (141390577..141405507, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene microtubule-actin crosslinking factor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene uncharacterized LOC120103124 Neighboring gene akirin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death. Huang G, et al. Cell Death Differ, 2007 Feb. PMID 16826196
  2. Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns. Triepels RH, et al. J Biol Chem, 2001 Mar 23. PMID 11112787
  3. Accessory subunits are integral for assembly and function of human mitochondrial complex I. Stroud DA, et al. Nature, 2016 Oct 6. PMID 27626371
  4. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. Murray J, et al. J Biol Chem, 2003 Apr 18. PMID 12611891
  5. Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2). Guo R, et al. Cell, 2017 Sep 7. PMID 28844695

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Names
NADH dehydrogenase (ubiquinone) Fe-S protein 5
NADH dehydrogenase (ubiquinone) Fe-S protein 5b, 15kDa (NADH-coenzyme Q reductase)
NP_001025223.1
XP_006238889.1
XP_006238890.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030052.1 → NP_001025223.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

    See identical proteins and their annotated locations for NP_001025223.1

    Status: PROVISIONAL

    Source sequence(s)
    AW525881, CB716681
    UniProtKB/TrEMBL
    A0A0G2JZJ9, A0A9K3Y8A9, B5DEL8
    Related
    ENSRNOP00000037699.4, ENSRNOT00000036389.7
    Conserved Domains (1) summary
    pfam10200
    Location:2 → 96
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    141258828..141264552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238827.5 → XP_006238889.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006238889.1

    UniProtKB/TrEMBL
    A0A0G2JZJ9, A0A9K3Y8A9, B5DEL8
    Conserved Domains (1) summary
    pfam10200
    Location:2 → 96
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

  2. XM_006238828.5 → XP_006238890.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006238890.1

    UniProtKB/TrEMBL
    A0A0G2JZJ9, A0A9K3Y8A9, B5DEL8
    Conserved Domains (1) summary
    pfam10200
    Location:2 → 96
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
Nucleotide Protein Strain
Heading Accession and Version

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