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Gnl2 G protein nucleolar 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362593, updated on 17-Aug-2024

Summary

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Official Symbol
Gnl2provided by RGD
Official Full Name
G protein nucleolar 2provided by RGD
Primary source
RGD:1305006
See related
EnsemblRapid:ENSRNOG00000009430 AllianceGenome:RGD:1305006
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305006
Summary
Predicted to enable GTP binding activity. Predicted to be active in nucleolus. Orthologous to human GNL2 (G protein nucleolar 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 209.5), Kidney (RPKM 119.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gnl2 in Genome Data Viewer
Location:
5q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (142577798..142603185)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (137293141..137318528)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (143027970..143053418)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene R-spondin 1 Neighboring gene uncharacterized LOC108351029 Neighboring gene dynein, axonemal, light intermediate chain 1 Neighboring gene Smad nuclear interacting protein 1 Neighboring gene MYST/Esa1-associated factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export. Matsuo Y, et al. Nature, 2014 Jan 2. PMID 24240281, Free PMC Article
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC116342

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleolar GTP-binding protein 2
Names
guanine nucleotide binding protein-like 2 (nucleolar)
nucleolar GTPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025736.1 → NP_001020907.1  nucleolar GTP-binding protein 2

    See identical proteins and their annotated locations for NP_001020907.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099173
    UniProtKB/TrEMBL
    Q4KLJ3
    Related
    ENSRNOP00000012702.5, ENSRNOT00000012702.8
    Conserved Domains (3) summary
    cd01858
    Location:209 → 365
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:190 → 488
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    pfam08153
    Location:44 → 174
    NGP1NT; NGP1NT (NUC091) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    142577798..142603185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110345.2 → XP_038966273.1  nucleolar GTP-binding protein 2 isoform X1

    Conserved Domains (2) summary
    cd01858
    Location:50 → 206
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    COG1160
    Location:157 → 262
    Der; Predicted GTPases [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version

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