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Heatr5b HEAT repeat containing 5B [ Rattus norvegicus (Norway rat) ]

Gene ID: 362683, updated on 2-Nov-2024

Summary

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Official Symbol
Heatr5bprovided by RGD
Official Full Name
HEAT repeat containing 5Bprovided by RGD
Primary source
RGD:1359216
See related
EnsemblRapid:ENSRNOG00000025926 AllianceGenome:RGD:1359216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in endocytosis; protein localization; and retrograde transport, endosome to Golgi. Predicted to be located in cytosol and nuclear speck. Predicted to be active in endocytic vesicle. Orthologous to human HEATR5B (HEAT repeat containing 5B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 88.7), Adrenal (RPKM 82.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Heatr5b in Genome Data Viewer
Location:
6q12
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (21995558..22075582)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (16243424..16323444)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (1330314..1410339, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene keratin-associated protein 5-1-like Neighboring gene sulfotransferase family 6B member 1 Neighboring gene uncharacterized LOC120103477 Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 2 Neighboring gene G patch domain containing 11 Neighboring gene striatin Neighboring gene vitrin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HEAT repeat-containing protein 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191064.3 → NP_001177993.2  HEAT repeat-containing protein 5B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    F1LST0
    Related
    ENSRNOP00000035203.6, ENSRNOT00000035905.7
    Conserved Domains (1) summary
    sd00044
    Location:813 → 843
    HEAT; HEAT repeat [structural motif]

  2. NM_001414953.1 → NP_001401882.1  HEAT repeat-containing protein 5B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6GJQ5
    Related
    ENSRNOP00000092384.1, ENSRNOT00000098374.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    21995558..22075582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112448.2 → XP_038968376.1  HEAT repeat-containing protein 5B isoform X1

    Conserved Domains (1) summary
    sd00044
    Location:852 → 882
    HEAT; HEAT repeat [structural motif]

  2. XM_039112449.2 → XP_038968377.1  HEAT repeat-containing protein 5B isoform X2

    Conserved Domains (1) summary
    sd00044
    Location:852 → 882
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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