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Cebpz CCAAT/enhancer binding protein zeta [ Rattus norvegicus (Norway rat) ]

Gene ID: 362686, updated on 17-Aug-2024

Summary

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Official Symbol
Cebpzprovided by RGD
Official Full Name
CCAAT/enhancer binding protein zetaprovided by RGD
Primary source
RGD:1304994
See related
EnsemblRapid:ENSRNOG00000005087 AllianceGenome:RGD:1304994
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cbf
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 164.5), Spleen (RPKM 145.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (21872071..21889755)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (16119871..16137600)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (1516804..1534488, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene protein kinase D3 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene CEBPZ opposite strand Neighboring gene heterogeneous nuclear ribonucleoprotein F, pseudogene 4 Neighboring gene sulfotransferase family 6B member 1 Neighboring gene keratin-associated protein 5-1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes. Yamamoto CM, et al. J Leukoc Biol, 2004 Feb. PMID 14634060
  2. A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter. Lum LS, et al. Mol Cell Biol, 1990 Dec. PMID 2247079, Free PMC Article
  3. The CCAAT-binding proteins CP1 and NF-I cooperate with ATF-2 in the transcription of the fibronectin gene. Alonso CR, et al. J Biol Chem, 1996 Sep 6. PMID 8703044
  4. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, et al. Proteomics, 2005 Jul. PMID 15942958
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. demonstrated that proximity of the CAAT box and a putative polyoma enhancer-binding protein 2/core-binding factor PEBP2/CBF site was important for defensin NP-3 promoter activity.
    Title: Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CCAAT-binding factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CCAAT/enhancer-binding protein zeta
Names
core-binding factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108701.1 → NP_001102171.1  CCAAT/enhancer-binding protein zeta

    See identical proteins and their annotated locations for NP_001102171.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/TrEMBL
    A6H9U7, D3ZNU1
    Related
    ENSRNOP00000006824.4, ENSRNOT00000006824.7
    Conserved Domains (3) summary
    COG5593
    Location:105 → 981
    COG5593; Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis]
    pfam03914
    Location:517 → 726
    CBF; CBF/Mak21 family
    cl17018
    Location:269 → 430
    FANC; Fanconi anemia ID complex proteins FANCI and FANCD2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    21872071..21889755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112455.2 → XP_038968383.1  CCAAT/enhancer-binding protein zeta isoform X1

    Conserved Domains (1) summary
    cl27223
    Location:105 → 543
    CBF; CBF/Mak21 family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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