U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gemin6 gem (nuclear organelle) associated protein 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362688, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Gemin6provided by RGD
Official Full Name
gem (nuclear organelle) associated protein 6provided by RGD
Primary source
RGD:1311168
See related
EnsemblRapid:ENSRNOG00000027332 AllianceGenome:RGD:1311168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in Gemini of coiled bodies and cytosol. Predicted to be part of SMN complex. Orthologous to human GEMIN6 (gem nuclear organelle associated protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 132.9), Liver (RPKM 131.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gemin6 in Genome Data Viewer
Location:
6q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20538325..20542867, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14786090..14790617, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (2907040..2911577)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene eukaryotic translation initiation factor 4A2, pseudogene 2 Neighboring gene MORN repeat containing 2 Neighboring gene DExH-box helicase 57 Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene serine and arginine rich splicing factor 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis. Yong J, et al. Mol Cell, 2010 May 28. PMID 20513430, Free PMC Article
  2. Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. Pellizzoni L, et al. J Biol Chem, 2002 Mar 1. PMID 11748230
  3. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Chari A, et al. Cell, 2008 Oct 31. PMID 18984161
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in spliceosomal complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Gemini of coiled bodies ISO
Inferred from Sequence Orthology
more info
  
part_of SMN complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SMN complex ISO
Inferred from Sequence Orthology
more info
  
part_of SMN-Sm protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
gem-associated protein 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009466.3 → NP_001009466.2  gem-associated protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6H9R3, G3V972, Q5JCM4
    Related
    ENSRNOP00000037414.2, ENSRNOT00000037739.4
    Conserved Domains (1) summary
    pfam06372
    Location:1 → 166
    Gemin6; Gemin6 protein

  2. NM_001395136.1 → NP_001382065.1  gem-associated protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6H9R3, G3V972, Q5JCM4
    Conserved Domains (1) summary
    pfam06372
    Location:1 → 166
    Gemin6; Gemin6 protein

  3. NM_001395137.1 → NP_001382066.1  gem-associated protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    Related
    ENSRNOP00000111913.1, ENSRNOT00000159966.1
    Conserved Domains (1) summary
    cl00259
    Location:1 → 107
    Sm_like; Sm and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    20538325..20542867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262048.1 → XP_063118118.1  gem-associated protein 6 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools