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Ppp1r21 protein phosphatase 1, regulatory subunit 21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362697, updated on 10-Jul-2024

Summary

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Official Symbol
Ppp1r21provided by RGD
Official Full Name
protein phosphatase 1, regulatory subunit 21provided by RGD
Primary source
RGD:1565310
See related
EnsemblRapid:ENSRNOG00000016528 AllianceGenome:RGD:1565310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565310
Summary
Predicted to be active in early endosome. Orthologous to human PPP1R21 (protein phosphatase 1 regulatory subunit 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 105.8), Thymus (RPKM 95.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp1r21 in Genome Data Viewer
Location:
6q12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (11655059..11724219, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (5901518..5970684, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (12253788..12323427)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene stonin 1 Neighboring gene uncharacterized LOC134479304 Neighboring gene ubiquitin-conjugating enzyme E2S, pseudogene 2 Neighboring gene uncharacterized LOC102546644 Neighboring gene forkhead box N2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Biallelic loss of function variants in PPP1R21 cause a neurodevelopmental syndrome with impaired endocytic function. Rehman AU, et al. Hum Mutat, 2019 Mar. PMID 30520571, Free PMC Article
  2. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Bithell A, et al. Brain Res Dev Brain Res, 2003 Dec 19. PMID 14643017
  3. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271305.1 → NP_001258234.1  protein phosphatase 1 regulatory subunit 21

    See identical proteins and their annotated locations for NP_001258234.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6B588, A6H9C0, F1LYZ8
    Related
    ENSRNOP00000058387.4, ENSRNOT00000061675.7
    Conserved Domains (2) summary
    pfam10205
    Location:11 → 111
    KLRAQ; Predicted coiled-coil domain-containing protein
    pfam10212
    Location:255 → 771
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    11655059..11724219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764482.4 → XP_008762704.1  protein phosphatase 1 regulatory subunit 21 isoform X1

    UniProtKB/TrEMBL
    A0A8I6B588
    Conserved Domains (2) summary
    pfam10205
    Location:1 → 65
    KLRAQ; Predicted coiled-coil domain-containing protein
    pfam10212
    Location:209 → 725
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein
Nucleotide Protein Strain
Heading Accession and Version

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