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Drc1 dynein regulatory complex subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362712, updated on 2-Nov-2024

Summary

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Official Symbol
Drc1provided by RGD
Official Full Name
dynein regulatory complex subunit 1provided by RGD
Primary source
RGD:1359318
See related
EnsemblRapid:ENSRNOG00000024905 AllianceGenome:RGD:1359318
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc164
Summary
Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to act upstream of or within several processes, including cilium assembly; determination of left/right symmetry; and single fertilization. Predicted to be located in motile cilium. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme; cytosol; and sperm flagellum. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 21 and spermatogenic failure 80. Orthologous to human DRC1 (dynein regulatory complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 246.5), Lung (RPKM 36.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Drc1 in Genome Data Viewer
Location:
6q14
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (31744849..31779996, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (26025004..26059438, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (27425237..27460038, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ciliary microtubule inner protein 2C Neighboring gene otoferlin Neighboring gene selenoprotein I Neighboring gene uncharacterized LOC120103489

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans. Wirschell M, et al. Nat Genet, 2013 Mar. PMID 23354437, Free PMC Article
  2. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
  3. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94915

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in axonemal dynein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonemal dynein complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in axonemal dynein complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in axonemal dynein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within axoneme assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cilium organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium-dependent cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium-dependent cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium-dependent cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium-dependent cell motility ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within single fertilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sperm flagellum assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of axonemal dynein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynein regulatory complex protein 1
Names
coiled-coil domain containing 164
coiled-coil domain-containing protein 164
dynein regulatory complex subunit 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007009.1 → NP_001007010.1  dynein regulatory complex protein 1

    See identical proteins and their annotated locations for NP_001007010.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083825
    UniProtKB/Swiss-Prot
    Q5XI65
    UniProtKB/TrEMBL
    A0A8I6AGD8
    Related
    ENSRNOP00000031362.4, ENSRNOT00000036815.7
    Conserved Domains (2) summary
    pfam14772
    Location:100 → 200
    NYD-SP28; Sperm tail
    pfam14775
    Location:674 → 732
    NYD-SP28_assoc; Sperm tail C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    31744849..31779996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112484.2 → XP_038968412.1  dynein regulatory complex protein 1 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:117 → 365
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam14772
    Location:100 → 200
    NYD-SP28; Sperm tail
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI65.1 GenPept UniProtKB/Swiss-Prot:Q5XI65

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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